Can cycling and counseling curb opioid cravings?

NCT ID NCT05688410

Ongoing Symptom relief Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or together. Researchers will also check if these treatments improve depression, anxiety, and sleep.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise (stationary cycling) and psychotherapy (I-STOP)
What this could lead to: If it works, this could point toward a non-drug way to help people in treatment for opioid addiction manage cravings and pain.
What could go wrong: This is an early-stage trial with only 198 participants, so results may not apply to everyone. The effects may be small or not last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic pain syndrome opiate dependence Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER PAIN

Contacts and locations

Locations

Case Western Reserve University

Cleveland, Ohio, 44106, United States
University of Colorado at Denver

Denver, Colorado, 80217, United States

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