CHRONIC PAIN

This study tested whether adding Dermabond (a medical glue) to stitches helps keep spinal cord stimulator leads from moving after placement. 57 adults with chronic pain had their leads secured either with stitches alone or with stitches plus glue. The main goal was to measure how…

This study looked at whether medical cannabis can help people with chronic pain reduce their use of opioid painkillers. 29 patients who wanted to lower their opioid dose but couldn't afford medical cannabis were given access to it. Over 5 months, doctors tracked their pain levels…

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This completed study tested whether reducing loneliness through group therapy could lower opioid misuse in 102 adults on long-term opioids for chronic pain. Participants received either cognitive behavior therapy or social navigation in weekly sessions. Researchers measured chang…

This study tested 776 people with chronic pain of unknown cause to see if they had Fabry disease, a rare inherited disorder that can cause pain, kidney, heart, and nerve problems. Researchers used enzyme tests in men and genetic tests in women to find cases. The goal was to see h…

This pilot study tested whether giving vitamin D shortly after a burn injury could prevent chronic pain. Forty adults with burns took either vitamin D or a placebo and were followed for six months. Researchers also studied how vitamin D affects the immune system after a burn. The…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study investigates whether adding focal muscle vibration to shoulder exercises can improve how the brain processes sensory and movement signals in people with chronic subacromial impingement syndrome. Participants will receive 12 sessions of either vibration-assisted exercis…

This small pilot study tested a mindfulness-based therapy designed for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nin…

This study tested two different methods for placing a spinal cord stimulator (SCS) lead in people with chronic back pain. One method uses the patient's sensation of tingling (paresthesia) to guide placement, while the other uses the spine's natural midline as a guide. Sixty adult…

This study tested whether a 12-week lifestyle-based physical activity program before intensive rehabilitation helps people with chronic low back pain. Twenty-four adults were split into two groups: one did the preparatory program followed by intensive rehab, the other did only th…

This study tested two virtual, 8-week programs (Active Brains 1 and 2) in 267 older adults with chronic pain and early cognitive decline. Both programs taught skills like relaxation, cognitive training, and positive psychology to help manage symptoms. Researchers measured changes…

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This completed trial tested whether a Whole Health Team (WHT) approach helps veterans with chronic pain improve their daily functioning and quality of life compared to group education or usual care. Over 790 veterans from six VA sites participated, with follow-up lasting 12 month…

This study tested a program called RESET, led by community health workers, to improve physical and mental well-being in older adults. Over 450 African American adults aged 50+ with symptoms like depression, anxiety, or chronic pain took part. The program included weekly group pho…

This study tested whether tailoring magnetic brain stimulation to each person's brain signals can better relieve chronic pain. Researchers measured brain activity before treatment to customize the stimulation. 90 adults with chronic pain took part. The goal was to see if this per…

This study tested a telehealth program (CBT-TS) to help 300 veterans on long-term opioids for chronic pain feel more willing to try non-drug treatments like therapy or exercise. The goal was to reduce pain and reliance on opioids. Results will show if changing beliefs about these…

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested a 7-week program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly phone coaching and watched educational videos. The goal was to see if the program was practical and could reduce how much…

This study looked at whether playing music of a patient's choice during lumbar interventional procedures (like epidural steroid injections) could reduce pain and anxiety in people with chronic back pain. Thirty adults were randomly assigned to hear music or no music during their …

This study tested whether community health workers (CHWs) can teach older adults with chronic pain how to manage their symptoms using a 7-week program called STEPS. The program included phone sessions with a CHW, online videos, and a wearable activity tracker. Researchers enrolle…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This study tested whether a short motivational interview combined with self-management techniques could help Hungarian teens aged 12-18 who have had chronic pain for at least 3 months. The program included a 30-minute in-person session plus two follow-up phone calls. Researchers …

This study tested a program that teaches people with chronic muscle and joint pain how to actively cope with their condition using education, gentle movement, and behavioral strategies. 169 adults took part, comparing the program to usual care. The goal was to see if it could red…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study from Harvard University tested whether mindfully noticing changes in pain throughout the day can help people with chronic pain feel more in control and reduce pain intensity. 300 adults with chronic pain for at least six months were split into groups that either paid c…

This study tested the DOZE app, a digital self-management program designed to improve sleep in young adults aged 18-25 with chronic pain and insomnia. Forty participants used the app and a sleep diary for 10 weeks. The goal was to see if the app is easy to use and helps with pain…

This study tested a smartphone app and website called iCanCope with Pain, designed to help teens and young adults (ages 15-25) manage chronic pain. The app lets users track pain, sleep, mood, and activity, set goals, and learn coping strategies. The goal was to see if the program…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study tested whether attending weekly group mindfulness sessions could improve function and reduce pain for people with chronic low back pain. Over 450 adults took part, comparing group mindfulness with usual one-on-one care. The goal was to see if this approach helps people…

This study compared using 3 points versus 1 point to fix a lightweight mesh during laparoscopic hernia repair (TAPP) in 351 adults with a first-time inguinal hernia. The goal was to see which method leads to less pain, fewer complications like seroma or infection, and lower recur…

This study tested a group breathwork program for people with chronic musculoskeletal pain. 35 adults participated to see if the program was feasible, acceptable, and could help reduce pain. The goal was to develop a simple, group-based breathing technique that might ease symptoms…

This study looked at whether adding electrical dry needling to therapeutic exercise helps people with long-term neck pain more than exercise alone. 90 adults with chronic neck pain took part. The goal was to see if the combined treatment improves daily function and reduces pain b…

This study tested a new drug called ST-01, given as a shot into the spermatic cord every 28 days, to see if it safely reduces chronic scrotal pain better than standard lidocaine. 63 men with pain lasting over 3 months took part. The main goal was to measure pain changes using a 0…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a mobile app designed to help people with chronic pain better manage their symptoms and reduce how much pain interferes with daily life. The app uses proven therapy techniques like Acceptance and Commitment Therapy and Cognitive Behavioral Therapy, plus tools to…

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This study tested two at-home digital programs for chronic pain: a virtual reality (VR) program and a self-guided online course. 330 adults with chronic pain used one of the programs for 8 weeks. Researchers measured changes in pain intensity and how pain affected daily life. The…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study tested a 10-week education program designed to help Korean Americans with chronic pain. The program taught coping strategies and pain management skills in group sessions held at community centers. Researchers wanted to see if the program was feasible and acceptable, an…

This study tested two procedures—cryoablation (freezing nerves) and endoscopic denervation (cutting nerves)—to treat chronic sacroiliac joint pain. 51 adults with confirmed pain from the joint were included. The goal was to see which method better reduces pain and improves daily …

This study tested two ways to give steroid injections for mild-to-moderate carpal tunnel syndrome: one guided by ultrasound into the wrist, and one into the buttock muscle. 63 adults with symptoms like numbness and pain were followed to see which method improved pain, hand functi…

This study looked at whether Tai Chi, a gentle mind-body exercise, can help adults over 45 living with both HIV and chronic pain. Researchers tested the program with 36 participants to see if it was practical and liked by patients. The goal was to find a non-drug way to reduce pa…

This study compared cognitive functional therapy (CFT) to conventional therapy for adults with chronic neck pain lasting over 3 months. Sixty participants were randomly assigned to one of the two treatments. CFT combines physical exercises with psychological strategies to help pa…

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study tested different treatment sequences for chronic low back pain in 749 adults. Participants first received either physical therapy or cognitive behavioral therapy. Those who didn't improve were switched to the other therapy or added mindfulness. The goal was to find whi…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This completed study compared an 8-week online yoga program to a conventional exercise routine in 52 women with endometriosis. The goal was to see if yoga could better reduce pain and improve quality of life. Participants practiced meditation, breathing, and gentle poses, while t…

This study tested a new program called Mindful Action for Pain (MAP) in 126 veterans with chronic pain. MAP combines mindfulness meditation with techniques from acceptance and commitment therapy to help people better manage pain and improve daily function. The goal was to see if …

This study compared two types of needle therapy—pharmacopuncture (injecting herbal extracts) and standard acupuncture—for people with chronic neck pain lasting over three months. A total of 128 adults took part, and the main goal was to see which approach reduced pain more after …

This study tested a 12-week virtual program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Forty veterans participated in weekly group sessions and coaching via video. The goal was to see if the program is feasible and acceptable, not yet to…

This study looked at whether a mobile cognitive behavioral therapy (CBT) program, combined with a gentle brain stimulation technique called tDCS, could help teens who survived bone cancer manage chronic pain. Researchers first adapted the program for Black and Hispanic teens, the…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study tested whether a virtual yoga program could help people with chronic pain. 94 participants with pain lasting over 6 months took part in 8 weeks of remote yoga classes and daily 30-minute video-guided practice. Researchers measured how feasible the program was and wheth…

This study tested whether a 10-week mind-body walking program (GetActive-Fitbit) is feasible for adults with chronic musculoskeletal pain. 92 participants were randomly assigned to either the walking program or a health education group. The goal was to see if people would join, s…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study tested a new program to help older adults manage chronic pain using educational podcasts and support from a community health worker. 40 people aged 50 and older with long-lasting pain took part. The program aimed to teach pain self-management skills and help participan…

This study tested two treatments for people with chronic neck pain that lasts at least 3 months. One group received a treatment called percutaneous neuromodulation, which uses tiny needles to stimulate nerves. The other group did only therapeutic exercises. The goal was to see wh…

This study tested two types of telehealth programs for people with chronic pain: an online self-guided program and live sessions led by a health coach via phone or video. Over 2,300 adults from four healthcare systems took part. The goal was to see if these programs could help re…

This study tested a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve, which helps control pain and stress. Thirty adults with fibromyalgia received either real or sham stimulation for 30 minutes daily, five days a week, over four weeks…

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This study tested whether a non-invasive brain stimulation method called tDCS can help relieve chronic pelvic pain in women with endometriosis. Thirty women who were already on hormone therapy and had daily pain scores above 4 out of 10 took part. They received multiple tDCS sess…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This pilot study tested a mindfulness-based cognitive therapy program, called Quiet Focus, in 12 older Black adults with chronic pain and mild depression. The goal was to see if the program is acceptable and helpful, and to gather information for a larger future study. Participan…

This study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…

This study looked at a voluntary program to help people with chronic pain slowly lower their opioid medications. 51 adults who wanted to reduce their opioid dose worked with their doctor over 4 months using a personalized tapering plan and a self-help book. The main goal was to s…

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This completed study tested two types of telehealth cognitive behavioral therapy (CBT) in 48 veterans with chronic pain who also felt lonely. One therapy focused on loneliness, the other on coping with pain. Researchers measured changes in loneliness, social interactions, and pai…

This study tested whether a toolkit called Pain at Work (PAW) can help employees with chronic pain manage their symptoms and stay productive. Around 380 workers from different workplaces in England took part, with some using the toolkit plus support calls and others receiving usu…

This study tested a 4-week mental imagery training program in 34 adults (17 with chronic neck pain, 17 healthy). The training involved imagining neck movements to retrain the brain. Researchers measured pain, movement accuracy, fear of movement, and brain activity before and afte…

This study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This study tested whether a mindfulness-based group therapy program, originally developed in Canada, could work for French teenagers aged 12-17 with chronic pain. The main goal was to see if teens would attend at least 6 out of 8 sessions. Researchers also looked at effects on pa…

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study tested different ways to help people on medication for opioid use disorder do more yoga to manage their chronic pain. 192 adults who had been in treatment for at least 3 months took part. The goal was to see which combination of support methods helped them practice yog…

This study tested two methods to prevent chronic pain after thyroid removal: a nerve block (superficial cervical plexus block) and the drug ketamine. 69 adults having thyroid surgery were randomly assigned to one of the two approaches. The main goal was to see which method better…

This study tested whether adding virtual reality to standard physiotherapy could help teenagers with chronic musculoskeletal pain. 34 teens aged 10-17 took part in up to 8 sessions over 6-12 weeks. The goal was to see if VR was practical and enjoyable, and whether it could improv…

This study looked at whether giving doctors information about what matters to older Veterans with chronic pain—like how they store medications and what help they get at home—can improve pain care. Researchers talked to 230 Veterans aged 65 and older, their caregivers, and clinici…

This study compared two antidepressant medications, duloxetine and desipramine, to see which one reduces pain better in people with chronic pain. About 86 adults with pain lasting more than 3 months took one of the two drugs for six months. The main goal was to see how many peopl…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested whether adding a stellate ganglion block (a numbing injection in the neck) to cognitive processing therapy (a type of talk therapy) helps reduce PTSD and chronic pain more than therapy alone. Sixty adults with PTSD took part. The goal was to see if the combinati…

This study tested a mind-body program called GetActive for adults with chronic pain. The program combines relaxation techniques, coping skills, and physical activity (with or without a Fitbit). 82 participants completed the program, and researchers measured satisfaction, safety, …

This study tested whether combining a non-opioid pain medication (duloxetine) with an online pain-coping skills program helps people with long-term muscle and joint pain. 280 adults with daily pain for at least 3 months took part. The goal was to see if this approach reduces pain…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The workshop taught coping strategies to reduce distress and improve reintegration into civilian life. 176 veterans…

This study looked at whether offering telehealth sessions of massage, yoga, chiropractic, or physical therapy could help adults with chronic pain reduce their opioid use and feel better. Twenty-one people participated, and researchers tracked changes in pain intensity, pain inter…

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study tested a smartphone app designed to help people who have both chronic pain and heavy drinking habits. Researchers wanted to see if the app was easy and acceptable to use, especially for people in rural areas. The study involved 32 participants who used the app for 8 we…

This study looked at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illnesses like schizophrenia or bipolar disorder manage chronic pain. 47 veterans took part in a 12-session CBT program designed for chronic pain. The goal was to see if the ther…

This study tested whether giving adults with chronic pain a user guide and weekly prompts helps them use an online pain-management resource more effectively. 99 participants were split into two groups: one got the guide and prompts, the other just the online resource. Researchers…

This study tested whether a painless brain stimulation technique called tDCS could help veterans suffering from chronic pain, PTSD, and depression. 38 veterans received tDCS sessions during an intensive outpatient program. Researchers measured changes in pain levels and mental he…

This study developed and tested a mobile website called LIMIT to help veterans on long-term opioid therapy safely reduce their opioid use while managing chronic pain. 44 veterans participated, using either the LIMIT app or a pain diary app. The goal was to see if the tool is acce…

This study tested whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if nitrous oxide, w…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study tracked 582 children aged 6 to 18 who had surgery to see how many still had pain 3 months later. Researchers used a pain questionnaire to measure pain levels and identify risk factors. The goal was to better understand chronic post-operative pain in kids, not to test a…

This study tested whether wearable devices can be used to monitor activity in older adults with chronic low back pain. 30 participants wore ankle sensors to track movement and reported on their pain and mobility. The goal was to see if this approach is practical and acceptable fo…

This study talked to 50 adults with long-term (non-cancer) pain and their healthcare providers to learn about their experiences managing pain in primary care. The goal was to use this information to create a decision aid tool that helps patients and doctors make informed choices …

This study tested a new way to treat chronic pain without surgery or drugs. Researchers used low-intensity focused ultrasound (sound waves) to temporarily change brain activity in 61 adults with chronic pain. Participants had brain scans and then received mild heat pulses on thei…

This study looked at 202 Polish adults with chronic low back pain to find out how severe their anxiety symptoms are. Participants filled out a questionnaire called GAD-7, which scores anxiety from none to severe. The goal was simply to measure the problem, not to test any treatme…

This study gathered information from 73 adults with chronic pain who were already using or planning to use an approved medical device (like a spinal cord stimulator) for their pain. Researchers asked participants to report their pain levels on a 0-10 scale and other outcomes duri…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This study looked at whether the weekly performance of a favorite NFL team affects chronic pain in avid football fans. Thirty-two adults with chronic pain completed weekly surveys during the football season, rating their pain, mood, and pain-related thoughts. The goal was to see …

This pilot study tested a program called STEPPT to see if it could reduce ethnic disparities in physical therapy referrals and attendance for spine pain. The program included educating clinic staff, updating electronic health records to automate referrals, and providing patient n…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study tested whether wearable devices like the Apple Watch and Oura Ring, along with digital surveys, can predict outcomes for chronic pain patients receiving spinal cord stimulation. Twenty-eight adults with long-term pain were implanted with Abbott's spinal cord stimulator…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looked at 264 people with chronic lower back and leg pain caused by a pinched nerve. Researchers wanted to see if routine blood test results could predict who would get good pain relief from a combination of two treatments: a nerve block and a short electrical pulse to…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This completed study looked at 204 patients who had a kidney removed (nephrectomy) to find out what factors might lead to chronic pain lasting months or years after surgery. Researchers measured pain levels at 1 hour, 3 months, and 1 year after the operation using a simple 0-to-1…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This study looked at 158 adults to find out if certain traits or risk factors can predict who will develop chronic pain after lower back surgery. Researchers measured pain severity, disability, and other health factors using questionnaires. The goal was to better understand why s…

This study looked at 84 adults with chronic neck pain to see how central sensitization (a condition where the nervous system becomes overly sensitive) relates to pain intensity, thinking patterns, sleep quality, and jaw function. Researchers used questionnaires to measure these f…

This study looks at people who still have chronic back or leg pain after back surgery, a condition called Failed Back Surgery Syndrome (FBSS). Researchers want to better understand what causes this pain and how to diagnose it faster. They will collect detailed information from 20…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. 18 adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal was to s…

This study explored whether adding mindfulness training to physical therapy is practical for people with long-term muscle and joint pain who also take opioid painkillers. Researchers developed a training manual for physical therapists and tested different ways to teach them mindf…

This completed study from the University of Valencia looked at 133 adults with chronic pain to see if jaw (temporomandibular) pain is linked to pelvic pain. Participants filled out questionnaires about their pain, emotions, and sensitivity. The goal was to understand why these pa…

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either intravenous propofol or inhaled sevoflurane. Researchers measured pain right after surgery and over …

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study followed 392 adults who had planned surgeries to map their pain levels over the first 7 days after the operation. Researchers wanted to see if certain pain patterns could predict who would still have pain 3 months later. The goal is to better understand and possibly pr…

This study tested whether combining acupuncture with a gentle brain-stimulation technique (tDCS) can improve chronic low back pain more than either treatment alone. 116 adults with long-term back pain were split into four groups receiving different combinations of real or fake ac…

This study tested a computer tool that helps doctors and patients with chronic pain make treatment decisions together. The tool was used in primary care clinics for patients with long-term muscle or bone pain who had recently taken opioids. The goal was to see if clinics would ad…

This study looked at how oxytocin, a natural brain hormone, might reduce pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to create a model of how oxytocin …

This study tested a brief, computer-based personalized feedback program for adults with chronic pain who drink heavily and take prescription opioids. The program was designed to educate participants about the risks of mixing alcohol and opioids and to motivate them to reduce drin…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This study looked at whether the way a physiotherapist talks about virtual reality (VR) affects how chronic pain patients view the treatment. Researchers showed 115 patients one of two videos: one with positive, encouraging words about VR, and another with negative, discouraging …

This study looked at 44 people with shoulder pain from rotator cuff problems to see if their level of central sensitization (a heightened pain response in the nervous system) affected how well a steroid injection worked. Researchers measured pain sensitivity before the injection …

This completed study followed 477 women in Denmark who had a planned cesarean delivery. Researchers used text-message surveys to track pain levels, medication use, and how pain affected daily life over several months. The goal was to better understand how common persistent pain i…