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Could laughing gas ease pain after spine surgery for opioid users?

NCT ID NCT00210158

Completed Symptom relief Sponsor: Institut Bergonié Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if nitrous oxide, which blocks certain pain pathways, could help manage post-surgery pain better than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
nitrous oxide
What this could lead to
If it works, this could point toward a way to reduce pain and opioid needs after spine procedures for people already on opioids.
What could go wrong
This was a small, early-phase trial with only 39 participants, so results may not apply broadly. The effect may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN

Contacts and locations

Locations

  • Institut Bergonié - Centre Régional de Luttre Contre le Cancer DE Bordeaux et du Sud Ouest

    Bordeaux, 33076, France

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