Institut Bergonié

This study is testing whether combining an immunotherapy drug (atezolizumab), an immune-boosting agent (BDB001), and targeted radiation can help control advanced solid tumors. It includes people with pancreatic cancer, lung cancer, melanoma, bladder cancer, triple-negative breast…

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if the combination can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma types will ta…

This study is for people with a certain type of prostate cancer that is not too advanced but has features that make it more likely to come back. It tests whether adding a short course of the drug darolutamide to standard radiation therapy can better control the cancer. The main g…

This study tests whether giving extra chemotherapy before surgery can help prevent the spread of a rare cancer called soft-tissue sarcoma. It involves 351 adults with high-risk, removable tumors. Researchers compare standard treatment (3 chemo cycles before surgery) to an intensi…

This study tests whether adding a tumor-freezing procedure (cryoablation) to standard immunotherapy and chemotherapy helps people with advanced lung cancer live longer. About 214 adults with metastatic lung adenocarcinoma will be randomly assigned to receive either the standard d…

This study is testing whether high-intensity focused ultrasound (HIFU) can destroy small breast tumors before a patient's scheduled surgery. The goal is to see if this non-invasive, radiation-free technique can completely eliminate the cancer cells in the treated area. Fifteen pa…

This study tests a new, technology-supported care plan for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) along with other health problems. The goal is to see if this approach improves their quality of life after 6 months. About 720 participants …

This study is testing whether DNA mutations found in the blood (ctDNA) can help predict if breast cancer will return in patients who had chemotherapy before surgery. Researchers will take blood samples over time from 180 people whose tumors did not fully disappear after chemo. Th…

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if these proteins can help predict how the disease will progress. No new treatments are tested; the goal is to gather information that could improve futur…

This study gathers information from 30,000 breast cancer patients treated at Institut Bergonié since the 1990s. Researchers will analyze the data to learn about survival rates, treatment practices, and factors that affect the disease's outlook. The goal is to better understand br…

This study is developing artificial intelligence (AI) tools to help pathologists more accurately diagnose and predict the behavior of rare uterine smooth muscle tumors, including those that are hard to classify as benign or malignant. Researchers will train deep learning models o…

This study is building a huge national database of up to 150,000 sarcoma patients in France. Researchers will collect medical records, tumor samples, and treatment information to learn more about how sarcomas are treated and what affects patient outcomes. No new treatments or dru…

This study looks at a radioactive treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. Researchers want to measure how much radiation the tumor and healthy organs receive, and see if that affects how well the treatment works or causes side effect…

This study is for people with advanced colorectal or non-small cell lung cancer. It tests whether adding a special blood test (ctDNA) to regular scans helps doctors choose the best treatment. About 332 participants will be randomly assigned to either standard care or the extra bl…

This study is testing whether a genetic signature called CINSARC can help predict how well chemotherapy works in people with soft-tissue sarcomas. About 205 participants with non-spread tumors will receive chemotherapy before surgery, and researchers will track tumor response. Th…

This study aims to find genetic changes in the tumors of 10,000 adults with advanced solid tumors or blood cancers. Researchers will use advanced DNA testing to identify these changes and then try to match patients with early-phase clinical trials of drugs that target those speci…