Could more chemo stop sarcoma spread? new trial aims to find out

NCT ID NCT03805022

Recruiting now Disease control Sponsor: Institut Bergonié Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing whether adding three extra cycles of chemotherapy before surgery can help prevent cancer spread in people with high-risk soft-tissue sarcoma. About 351 participants will be randomly assigned to standard treatment or standard treatment plus extra chemo. The main goal is to see if the extra chemo improves how long people live without the cancer spreading.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Doxorubicin, ifosfamide, or dacarbazine (chemotherapy drugs)
What this could lead to: If successful, this could lead to a more effective chemotherapy regimen that delays or prevents cancer spread in high-risk soft-tissue sarcoma patients.
What could go wrong: This is an early Phase 3 trial, so results are not yet proven. Chemotherapy has significant side effects, and the extra cycles may not improve outcomes or could cause more harm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-METASTATIC SOFT-TISSUE SARCOMA RESECTABLE

Contacts and locations

Locations

CHRU Strasbourg
RECRUITING

Strasbourg, 67200, France
CHU Dupuytren
RECRUITING

Limoges, 87042, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Insitut du Cancer
RECRUITING

Montpellier, 34298, France
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Institut Claudius Regaud
RECRUITING

Toulouse, 31052, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94800, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13273, France
Institut de Cancérologie de l'Ouest - Site René Gauducheau
RECRUITING

Saint-Herblain, 44805, France