Institut Bergonié

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) can help control a rare soft-tissue cancer called leiomyosarcoma. 58 adults with advanced or spreading disease took part. The goal was to see if the combination could stop or shrink tumor…

This phase 2 trial tested whether combining two immunotherapy drugs, nivolumab and relatlimab, can help people with advanced or metastatic soft-tissue sarcoma. The study enrolled 68 adults whose tumors had a specific immune structure. Researchers measured how many patients had th…

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This early-phase trial tested whether adding the drug olaparib to standard radiation therapy is safe for people with advanced soft-tissue sarcoma that cannot be removed by surgery. 41 participants received olaparib pills alongside daily radiation for about 7.5 weeks. The main goa…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested a combination of two chemotherapy drugs—trabectedin and cyclophosphamide—in 50 adults with advanced soft-tissue sarcomas that had already been treated. The goal was to find a safe dose and see if the combo could stop or slow tumor growth. Results showed the trea…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study tested a procedure called radiofrequency ablation, which uses heat from a needle to destroy breast tumors, combined with hormone therapy. It included 21 elderly patients (over 70) who either declined or were not candidates for surgery. The main goal was to see if the c…

This phase 2 trial tested the drug pazopanib against a standard chemotherapy combination (vinblastine and methotrexate) in 72 adults with progressive desmoid tumors. Desmoid tumors are non-cancerous but can grow aggressively and come back after surgery. The study measured how man…

This early-phase trial tested the combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find a safe dose and check for side effects. Researchers also lo…

This phase 2 trial tested a two-step surgical procedure called delayed coloanal anastomosis (2SCA) in 124 patients with medium or lower rectal cancer. The goal was to see if this technique lowers the rate of dangerous leaks at the surgical connection and reduces the need for a co…

This study tested whether giving a higher dose (54 Gy) of a very precise type of radiation called helical tomotherapy before surgery could improve outcomes for people with retroperitoneal liposarcoma, a rare cancer in the abdomen. The 48 participants received the radiation and th…

This study looked at whether a simple blood test (liquid biopsy) can detect EGFR gene mutations in people with advanced non-small cell lung cancer. Researchers collected blood samples from 581 patients and compared the results with standard tissue testing. The goal was to see if …

This study looked at whether an MRI can detect breast cancer in women who have abnormal nipple discharge but normal mammograms and ultrasounds. 70 women with single-pore, non-milky, non-green discharge were given an MRI. The goal was to see how often a normal MRI meant no cancer …

This study tested whether using a contrast dye during ultrasound while operating on liver tumors from colorectal cancer helps surgeons make better decisions. 68 patients were enrolled, and doctors compared the surgical plan before and after the contrast-enhanced ultrasound. The g…

This study looked at whether combining a PET scan with an endoscopic ultrasound-guided needle biopsy can accurately diagnose suspicious lymph nodes in the chest. Researchers tested this less invasive approach in 75 patients who had abnormal lymph nodes on PET scans. The goal was …

This study tested whether telemedicine and connected watches can help monitor symptoms and improve quality of life for women with advanced breast cancer who live far from their cancer center. Fifteen patients reported symptoms weekly on a tablet, while a smartwatch tracked their …

This study looked at whether giving ketamine during anesthesia can reduce the need for morphine and lower pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps avoid morphine's side effects.

This study tested whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if nitrous oxide, w…

This study tested whether a numbing medicine called ropivacaine, given through a chest tube, can reduce severe pain after lung cancer surgery. 90 adults having a thoracotomy (chest opening) for cancer received either ropivacaine or a saltwater placebo every 6 hours for 2 days. Th…

This study aims to find biological markers that can predict whether the drug trabectedin will work in patients with certain types of soft-tissue sarcoma. Researchers will collect tumor biopsies and blood samples from 29 participants before and during treatment. The goal is to use…

This study examined whether certain gene variations (FCGR2A and FCGR3A) influence how well the drug cetuximab works in people with advanced upper aerodigestive tract cancers that have spread or come back. Researchers analyzed blood samples from 121 participants to look for these …

This completed observational study looked at 492 patients with metastatic gastrointestinal stromal tumors (GIST) in France between 1990 and 2018. Researchers analyzed real-world treatment patterns, including which drugs were used and in what order, and how many patients got acces…

This study looked back at the medical records of 545 patients with bone tumors that had spread (metastatic). The goal was to see how these patients were treated in real life and what their outcomes were. The study focused on three types of bone tumors: osteosarcoma, Ewing sarcoma…

This completed study looked at records from over 20,000 women with metastatic breast cancer in France. Researchers wanted to see if earlier measures of treatment success, like progression-free survival, could reliably predict overall survival. By comparing real-world data to clin…

This completed study examined tumor samples from 3820 people with advanced solid tumors to find how many have NTRK gene fusions. Researchers used genetic testing to identify these rare changes. The study did not test any treatment, but aims to guide future targeted therapy decisi…

This study looked at 631 advanced melanoma patients treated with immune checkpoint inhibitors. Researchers wanted to see if the time until a patient needs their next treatment or dies (TNT-D) is a good stand-in for overall survival. The goal was to find a quicker way to measure h…

This study looked at whether MRI scans can detect how well breast cancer responds to chemotherapy early in treatment. Sixteen women with invasive breast cancer received standard chemo before surgery, and their MRI results were checked by two radiologists. The goal was to see if M…

This study tested a questionnaire called PO-BADO that helps doctors and nurses talk with cancer patients and their caregivers. Researchers checked if the questionnaire gives consistent and reliable results. 252 adults with cancer who have a caregiver support time took part. The g…

This completed study examined how social, economic, and health factors affect cancer care and survival in 450 elderly patients in France. Researchers used data from cancer registries and long-term health studies to see who received treatment and who did not. The goal was to under…

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. Instead of focusing only on tumor shrinkage, they identified key areas like independence, memory, mood, and nutrition. The goal is to help future clinica…

This pilot study measured levels of a heart stress marker called NT-proBNP in 54 breast cancer patients during surgery. All patients had previously received anthracycline chemotherapy, which can weaken the heart. Researchers wanted to see if anesthesia might add extra stress. The…

This small study of 12 men with early-stage rectal cancer used a special device to measure nighttime erections three months after surgery. The goal was to objectively detect erectile dysfunction caused by cancer treatment, since patients and doctors often avoid discussing this is…

This study aims to create better statistical methods for determining how many participants are needed in clinical trials. It accounts for differences among patients, such as varying health risks or treatment responses. The goal is to make trials more reliable without testing any …

This study looked at whether FDG-PET CT scans can more accurately stage muscle invasive bladder cancer compared to standard CT scans. Researchers reviewed records of 130 patients who had PET CT scans at diagnosis. The goal was to see if PET CT better detects cancer spread to lymp…

This study looked at 228 women with ductal carcinoma in situ (DCIS) or micro-invasive DCIS who needed a mastectomy. Researchers wanted to see if doing a sentinel lymph node biopsy upfront could help avoid a more extensive axillary lymph node dissection later. The goal was to find…

This study looked back at medical records of over 2,100 patients with metastatic soft tissue sarcoma treated in France between 1990 and 2013. Researchers analyzed which treatments patients received, including chemotherapy and local therapies, and how long they lived. The goal is …

This study looked at how many hospital workers had COVID-19 antibodies and how long they lasted. Over 500 staff at a French cancer center gave blood samples and answered questionnaires at the start, 3 months, and 12 months. The goal was to understand immune response in people who…