Institut Bergonié

This study tested a pill called pazopanib in 72 people with desmoid tumors that were growing. Desmoid tumors are non-cancerous but can be aggressive and hard to treat. The goal was to see if pazopanib could stop the tumors from growing and help patients avoid surgery. Results foc…

This study tested a combination of two chemotherapy drugs (trabectedin and cyclophosphamide) in 50 adults with advanced soft-tissue sarcomas that had already been treated. The goal was to find the safest dose and see if the combination could stop the cancer from growing for at le…

This study tested a combination of two drugs (MK3475 and cyclophosphamide) in 129 people with advanced sarcomas that could not be removed by surgery or had spread. The goal was to see if the treatment could shrink tumors or stop them from growing for at least 6 months. The trial …

This study tested a combination of two drugs, durvalumab (an immunotherapy) and tazemetostat (an epigenetic therapy), in 164 adults with advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The goal was to see if the combo could shrink or stabilize tumors. …

This study tested a different surgical technique called delayed coloanal anastomosis for people with medium or lower rectal cancer. The goal was to see if it could lower the chance of a dangerous leak where the colon is reconnected, and reduce the need for a temporary or permanen…

This early-phase study tested the safety of adding the drug olaparib to standard radiation therapy for people with advanced soft-tissue sarcoma that could not be removed by surgery. 41 adults took part. The main goals were to find the highest safe dose of olaparib and to see how …

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) helps control advanced leiomyosarcoma, a rare soft-tissue cancer. Fifty-eight adults with metastatic or inoperable tumors took part. The goal was to see if the combination could stop tumo…

This study tested a combination of two immunotherapy drugs, nivolumab and relatlimab, in 68 adults with advanced soft-tissue sarcoma. The goal was to see if the combo could shrink tumors or stop them from growing for at least 6 months. Participants had a specific immune feature i…

This study tested a high-precision radiation treatment (helical tomotherapy) given before surgery for retroperitoneal liposarcoma, a rare cancer in the abdomen. The goal was to see if a higher radiation dose (54 Gy) could lower the chance of the cancer coming back. 48 adults with…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for early signs of tumor shrinkage.…

This study tested a non-surgical treatment for breast cancer in 21 patients aged 70 and older who could not or would not have surgery. Doctors used ultrasound to guide a needle that heats and destroys the tumor, combined with hormone therapy. The goal was to see if this approach …

This study looked at whether a care plan led by a geriatrician and a nurse could help older adults (70+) with cancer live longer and feel better. It included 792 people with different cancers like breast, lung, or prostate. The approach was compared to usual cancer care to see if…

This study looked at whether an MRI can accurately rule out breast cancer in women who have abnormal nipple discharge but normal mammogram and ultrasound results. 70 women with single-pore, non-milky, non-green discharge were given an MRI. The goal was to see how often a normal M…

This study looked at whether combining a PET scan with a guided needle biopsy using an endoscope (echoendoscopy) can accurately diagnose cancer in lymph nodes in the chest. 75 patients with suspicious lymph nodes on PET scans were enrolled. The goal was to see if this less invasi…

This study looked at whether MRI scans can detect early signs that chemotherapy is shrinking breast tumors. Sixteen women with invasive breast cancer received chemo before surgery, and their MRI results were checked after the second cycle. The goal was to see if MRI measurements …

This study tested whether a numbing medicine called ropivacaine, placed inside the chest during lung cancer surgery, can reduce severe pain afterward. 90 adults having lung surgery for cancer took part. The goal was to see if this simple method works and how much medicine gets in…

This study looked at whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who had been taking opioid pain medication for more than a month. The goal was to see if th…

This study tested whether adding ketamine to general anesthesia could reduce the need for morphine and lessen pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps control post-operative pain and lowe…

This study looked at whether using telemedicine (video calls), connected watches, and symptom tracking apps can help women with advanced breast cancer who live far from their cancer center. Fifteen women took part, and researchers measured their quality of life after 6 and 12 mon…

This study looked at 228 women with ductal carcinoma in situ (DCIS) who needed a mastectomy. The goal was to see if doing a sentinel lymph node biopsy before mastectomy could help some women avoid a more extensive lymph node removal later. The researchers measured how many women …

This study reviewed medical records of 545 patients aged 12 and older with bone tumors that had spread (metastatic osteosarcoma, Ewing sarcoma, or chondrosarcoma). The goal was to understand how these patients are treated in real-world clinics and what their outcomes are. Researc…

This completed study looked at nearly 4,000 people with advanced solid tumors to find how many had a specific genetic change called an NTRK fusion. Researchers used advanced DNA and RNA testing on tumor samples to count these fusions. The goal was to understand how common these g…

This study looked at whether certain anesthesia drugs might stress the heart in breast cancer patients who had prior chemotherapy with anthracyclines (a type of chemo known to affect the heart). Researchers measured a heart stress marker called BNP before, during, and after surge…

This study looked at whether adding a simple blood test (liquid biopsy) to the standard tissue test could help find more gene changes (EGFR mutations) in people with advanced lung cancer. Over 500 patients who had not yet been treated provided both blood and tissue samples. The g…

This study tested a questionnaire designed to help doctors talk about cancer with patients and their caregivers. Researchers wanted to see if the questionnaire was reliable and consistent when used by different nurses. The study included 252 adults with cancer who had a caregiver…

This study looked at medical records of 492 adults with metastatic GIST (a rare stomach or bowel cancer) treated in France between 1990 and 2018. Researchers wanted to understand which treatments patients actually received in real life, including targeted therapies and clinical t…

This study looked at how many hospital workers had antibodies from a past COVID-19 infection. Over 500 staff members at a French cancer center gave blood samples at the start, 3 months, and 12 months. The goal was to track immune response over time and understand exposure risks, …

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. They identified key areas like independence, memory, mood, and nutrition that are often overlooked in traditional trials. The goal is to help future stud…

This study examined whether FDG-PET CT scans are more accurate than standard CT scans for detecting cancer spread in people with muscle invasive bladder cancer. Researchers reviewed records of 130 patients from two hospitals in France. The goal was to see if PET CT could help doc…

This study examined how social, economic, and health factors influence cancer treatment and survival in people aged 65 and older. Researchers analyzed data from 450 elderly cancer patients in France to see who received treatment and who survived one year after diagnosis. The goal…

This study created a better way to calculate how many people are needed in a clinical trial when patients have different risks or respond differently to treatment. Researchers analyzed data from 500 participants to improve trial design. The goal is to make future trials more reli…

This study looked at information from about 20,000 women with metastatic breast cancer to see if other measures of treatment success could replace the standard 'overall survival' endpoint. The goal was to find faster ways to tell if a treatment is working, which could help bring …

This study aimed to objectively measure erectile dysfunction in men treated for early-stage rectal cancer. Twelve sexually active men were monitored three months after surgery using a device that records nighttime erections. The goal was to better understand a common but often un…

This study aimed to find biological markers that could predict how well the drug trabectedin works in people with certain advanced soft-tissue sarcomas. Researchers collected tumor samples and blood from 29 adults before and during treatment to look for patterns. The goal was to …

This study looked at whether using a contrast dye during ultrasound, while surgeons operate on liver tumors that spread from colorectal cancer, helps them make better surgical decisions. 68 patients took part. The main goal was to see if the contrast ultrasound changed the planne…

This study explored whether small differences in a person's genes (called FCGR polymorphisms) can predict how well the drug cetuximab works for advanced head and neck cancers. Researchers analyzed blood samples from 121 patients to look for these gene variations and see if they w…

This study analyzed data from 631 cancer patients treated with immune-checkpoint inhibitors to see if the time until they needed a new treatment or died (TNT-D) could serve as a reliable substitute for overall survival in clinical trials. The research focused on previously untrea…

This study looked at over 2,000 patients with advanced soft tissue sarcoma to see how they were treated in everyday medical practice, not just in controlled trials. Researchers analyzed which treatments patients received, how long they worked, and overall survival. The goal is to…