New surgery for rectal cancer could cut leak risk and stoma need

NCT ID NCT01876901

Completed Disease control Sponsor: Institut Bergonié Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tested a two-step surgical procedure called delayed coloanal anastomosis (2SCA) in 124 patients with medium or lower rectal cancer. The goal was to see if this technique lowers the rate of dangerous leaks at the surgical connection and reduces the need for a colostomy bag. Results showed that the procedure may be safer than the standard immediate anastomosis, with fewer leaks and fewer patients needing a stoma.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 2-stage pull-through colo-anal anastomosis without prophylactic derivation (2SCA) - a surgical procedure
What this could lead to: If successful, this surgical technique could lower the risk of post-surgery leaks and reduce the need for temporary or permanent stomas in rectal cancer patients.
What could go wrong: This is a phase 2 trial with a relatively small sample size (124 patients). The results may not apply to all patients, and the procedure still carries surgical risks like infection or bleeding.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MEDIUM AND LOWER RECTAL CANCER

Contacts and locations

Locations

CHU DE BORDEAUX - Hôpital Saint André

Bordeaux, Aquitaine, 33000, France
CHU de GRENOBLE

Grenoble, Auvergne-Rhône-Alpes, 38000, France
Centre Alexis Vautrin

Vandœuvre-lès-Nancy, Lorraine, 54000, France
Centre Léon Bérard

Lyon, Auvergne-Rhône-Alpes, 69000, France
Chu de Nancy

Nancy, Lorraine, 54000, France
Clinique Du Tonkin

Villeurbanne, Auvergne-Rhône-Alpes, 69000, France
HOSPICES CIVILS DE LYON - Hôpital de la Croix Rousse

Lyon, Auvergne-Rhône-Alpes, 69000, France
Institut Bergonié

Bordeaux, Aquitaine, 33000, France
Institut Paoli Calmettes

Marseille, Bouche Du Rhône, 13000, France

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