Immunotherapy duo takes on rare sarcoma in new trial

NCT ID NCT04095208

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested whether combining two immunotherapy drugs, nivolumab and relatlimab, can help people with advanced or metastatic soft-tissue sarcoma. The study enrolled 68 adults whose tumors had a specific immune structure. Researchers measured how many patients had their cancer stop growing or shrink over six months. The goal is to find a new way to control this rare cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

nivolumab and relatlimab (immunotherapy drugs)

What this could lead to

If it works, this could offer a new treatment option for people with advanced soft-tissue sarcoma, potentially slowing the disease.

What could go wrong

This is a small, early-phase trial with only 68 participants. The drugs may not work for all sarcoma types, and side effects from immunotherapy can be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm Neoplasm Metastasis sarcoma soft tissue sarcoma Tertiary Lymphoid Structures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre Léon Bérard

    Lyon, 69000, France

  • Hôpital Cochin

    Paris, 75014, France

  • Institut Bergonié

    Bordeaux, 33000, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut de Cancérologie de l'Ouest - Site René Gauducheau

    Nantes, 44805, France