Gene signature may forecast chemo response in sarcoma patients

NCT ID NCT02789384

Recruiting now Knowledge-focused Sponsor: Institut Bergonié Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a genetic test called CINSARC can predict how well chemotherapy works in people with soft-tissue sarcoma. Researchers will collect tumor and blood samples from 205 participants before they receive standard chemotherapy and surgery. The goal is to see if the CINSARC signature matches how the tumor responds, which could help personalize treatment in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors better predict which sarcoma patients will benefit from chemotherapy before surgery.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and the genetic signature may not prove reliable enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOFT TISSUE SARCOMAS

Contacts and locations

Locations

AP-HM _ Hôpital de la Timone
RECRUITING

Marseille, 13385, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
NOT_YET_RECRUITING

Lille, 59020, France
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Claudius Regaud - IUCT-0
RECRUITING

Toulouse, 31052, France
Institut Curie
NOT_YET_RECRUITING

Paris, 75005, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13273, France
Institut de Cancérologie de l'Ouest
RECRUITING

Nantes, 44805, France

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