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New online tool aims to help those battling opioid addiction and chronic pain

NCT ID NCT05204576

Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researchers compared it to standard care alone in 160 adults to see if it helps them stay on their opioid treatment and reduces how much pain interferes with daily life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CBT4CBT-COPES (web-based cognitive behavioral therapy and pain self-management program)
What this could lead to
If it works, this could provide an accessible, low-cost way to help people with opioid use disorder and chronic pain stick with their medication and better manage pain.
What could go wrong
This is a completed early-stage trial with 160 participants, so results may not apply to everyone. The program is an add-on to standard care, not a replacement, and benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

160 people

The number who actually took part.

Started

Jul 2022

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Eligible participants will be 18 years of age or older * Meet DSM-5 criteria for OUD * Enrolled in methadone or buprenorphine treatment at Liberation * Have at least moderate-intensity chronic pain as indicated by a score of ≥ 4 over the past week on the 0-10 Numerical Rating Scale * Have pain on at least half of the days of the prior six months (indicating chronicity); * Self-reported ability to walk at least one block (for the exercise component of CBT4CBT-COPES Exclusion Criteria: * Inability to read, write, and speak English at a third grade level (for reading informed consent) * Untreated or inadequately treated bipolar or psychotic disorder or current suicide risk as identified by Structured Clinical Interview for DSM-5 (SCID-5) * Life threatening health conditions that would impede participation (e.g., end stage renal failure, malignant cancer requiring chemotherapy excluding melanoma) * Planned surgical treatment related to pain * Pending legal action or planned relocation that makes it unlikely they would be able to complete the study

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Opioid-use disorder

Contacts and locations

Locations

  • Connecticut Counseling Center

    Danbury, Connecticut, 06810, United States

  • Connecticut Counseling Centers

    Waterbury, Connecticut, 06701, United States

  • Liberation Programs

    Bridgeport, Connecticut, 06610, United States

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