Can a new pain drug safely team up with an opioid?

NCT ID NCT07751094

Not yet recruiting Disease control Sponsor: The Third Xiangya Hospital of Central South University Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial is testing an investigational drug called KL0011034, given by infusion, alongside the opioid alfentanil in people with moderate-to-severe chronic pain that is not caused by cancer. The study aims to see how the two drugs interact in the body, and whether the combination is safe and tolerable. It involves about 27 participants and is conducted in two parts: first to find a suitable dose, then to compare the drugs given alone and together.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KL0011034 injection (an investigational analgesic) combined with alfentanil hydrochloride injection (an opioid)
What this could lead to: If the combination proves safe and shows no harmful interactions, it could support further development of KL0011034 as a new option for managing chronic pain.
What could go wrong: This is an early-phase trial with a small number of participants, so results may not apply broadly. The drug may interact with alfentanil in unexpected ways, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN

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