Can Ultra-Low nicotine smokes help break the habit for those in pain?
NCT ID NCT06747871
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicotine or normal nicotine cigarettes for several weeks. Researchers will measure changes in smoking behavior, pain levels, and withdrawal symptoms to see if this approach could support quitting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Very low nicotine cigarettes (VLNC) vs. normal nicotine cigarettes (NNC)
What this could lead to
If it works, this could point toward a safer way to help people with chronic pain and opioid use disorder reduce or quit smoking.
What could go wrong
This is a small, early-phase study (60 people) that only looks at short-term effects. It may not lead to a proven cessation method, and switching to very low nicotine cigarettes might not reduce cravings or pain.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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North Pavilion
RECRUITINGDurham, North Carolina, 27705, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••