Can cannabis compounds help tame opioid cravings and chronic pain?
NCT ID NCT06544291
First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 3 times
Summary
This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a single dose of CBD (300mg or 600mg), THC, or a placebo in a controlled setting. Researchers will measure pain responses and craving levels over several hours to see if the cannabinoids offer relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- THC and CBD (cannabinoids)
- What this could lead to
- If it works, this could point toward a new treatment that helps people with opioid use disorder and chronic pain manage both conditions together.
- What could go wrong
- This is a small, early-phase trial (147 people) testing short-term effects only. The results may not lead to a lasting treatment, and cannabinoids can cause side effects like dizziness or impaired thinking.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Connecticut Mental Health Center
RECRUITINGNew Haven, Connecticut, 06519, United States
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