Can cannabis compounds help tame opioid cravings and chronic pain?
NCT ID NCT06544291
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a single dose of CBD (300mg or 600mg), THC, or a placebo in a controlled setting. Researchers will measure pain responses and craving levels over several hours to see if the cannabinoids offer relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
THC and CBD (cannabinoids)
What this could lead to
If it works, this could point toward a new treatment that helps people with opioid use disorder and chronic pain manage both conditions together.
What could go wrong
This is a small, early-phase trial (147 people) testing short-term effects only. The results may not lead to a lasting treatment, and cannabinoids can cause side effects like dizziness or impaired thinking.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Connecticut Mental Health Center
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••