Seeing pain: new scan aims to spotlight troublemaker nerves

NCT ID NCT07768501

First seen Aug 17, 2026 ยท Last updated Aug 17, 2026

Summary

This trial tests whether an investigational imaging agent called [18F]FTC-146, used with a PET/MRI scan, can identify the specific nerves responsible for chronic pain. Participants with chronic pain lasting at least two months will receive a single injection of the agent and undergo scans to look for signs of nerve irritation or injury. If a pain-generating nerve is found, they may receive a nerve block and a procedure called cryoneurolysis to temporarily interrupt pain signals. The goal is to see if this imaging approach can guide more precise pain treatments.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
[18F]FTC-146, an investigational imaging agent for PET/MRI scans
What this could lead to
If successful, this could lead to a new way to pinpoint the exact nerves causing chronic pain, enabling more targeted treatments like cryoneurolysis.
What could go wrong
This is an early-phase trial with only 6 participants, so results may not apply broadly. The imaging agent's effectiveness and safety are still uncertain.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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