CBD could help ease pain and cravings in opioid recovery
NCT ID NCT04587791
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a crossover design. The study focuses on safety, abuse potential, and effects on pain sensitivity and cognition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cannabidiol (CBD)
What this could lead to
If it works, this could point toward a safe way to help manage pain and reduce opioid cravings in people recovering from opioid addiction.
What could go wrong
This is a very early, small study with only 34 participants, so results may not apply widely. CBD may cause side effects or not improve pain or cravings at all.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Veterans Affairs Hospital
RECRUITINGWest Haven, Connecticut, 06516, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact