CBD could help ease pain and cravings in opioid recovery

NCT ID NCT04587791

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a crossover design. The study focuses on safety, abuse potential, and effects on pain sensitivity and cognition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabidiol (CBD)
What this could lead to: If it works, this could point toward a safe way to help manage pain and reduce opioid cravings in people recovering from opioid addiction.
What could go wrong: This is a very early, small study with only 34 participants, so results may not apply widely. CBD may cause side effects or not improve pain or cravings at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome opiate dependence Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN OPIOID-USE DISORDER

Contacts and locations

Locations

Department of Veterans Affairs Hospital
RECRUITING

West Haven, Connecticut, 06516, United States

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