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Could a diabetes drug ease stubborn tendon pain?

NCT ID NCT06100822

Recruiting now Symptom relief Sponsor: James Wang Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study is testing whether metformin, a common diabetes medicine, can reduce pain and help heal chronic Achilles tendon problems. Forty people with long-term tendon pain will take either metformin or a placebo pill for 16 weeks, along with a home exercise program. Researchers will measure changes in pain, function, and tendon thickness using ultrasound.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Metformin (extended-release capsules)
What this could lead to
If it works, this could point toward a new, low-cost treatment for chronic tendon pain using a common diabetes drug.
What could go wrong
This is a very early phase 1 trial with only 40 people. It may show no benefit over placebo, and metformin can cause stomach upset or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome disease of the tendon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACHILLES TENDINOPATHY CHRONIC PAIN TENDINOPATHY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

    Contact Email: •••••@•••••

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