Disease of the tendon

This trial investigates whether adding up to three corticosteroid injections to standard exercise therapy improves pain and function in adults with chronic midportion Achilles tendinopathy. Participants receive either the steroid injection or a placebo (lidocaine only), alongside…

This phase 2 trial tests a daily oral drug called pimicotinib in 20 Japanese adults with tenosynovial giant cell tumor (TGCT) that cannot be removed by surgery. The study aims to see if the drug is safe, how it moves through the body, and whether it shrinks tumors. Participants t…

This large real-world study is testing whether platelet-rich plasma (PRP) injections can reduce pain and improve function in people with chronic tendinopathies, including patellar, Achilles, elbow, and plantar fasciitis. Researchers will follow 2000 participants for 12 months, tr…

This study is testing a new medical device called the lok™ suture anchor system for repairing torn tendons and labrum in the shoulder. About 216 adults with rotator cuff tears, shoulder instability, or partial tendon avulsions will receive the anchors during surgery. Researchers …

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the best dose, while also seeing if the drug can shrink…

This study tests whether a dye called indocyanine green (ICG) can help surgeons see tenosynovial giant cell tumors (TGCT) during surgery. About 40 people with TGCT will get an ICG injection before their operation. The dye makes tumor tissue glow under a special camera, which surg…

This study aims to create a new scoring system called HASS to reliably diagnose long biceps tendon injuries before surgery. Currently, these injuries are hard to confirm without surgery, leading to uncertainty. Researchers will combine physical exam tests and imaging data from 20…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study is testing a gel called OSTENIL TENDON to see if it safely reduces pain and improves movement in people with tendon problems. Researchers will enroll 84 adults with one of four types of tendinopathy. The main goal is to measure pain changes three months after treatment…

This study compares two methods of pulsed radiofrequency treatment for the suprascapular nerve in people with chronic shoulder pain from rotator cuff problems. Thirty-two adults aged 40 to 80 will be randomly assigned to receive the treatment at either the suprascapular notch or …

This study tests whether a gentle brain stimulation technique called tDCS, applied before eccentric knee exercises, can improve pain and function more than exercise alone in people with patellar tendinopathy (jumper's knee). Forty-two adults with chronic knee pain will be randoml…

This study tests whether adding hyaluronic acid to a standard corticosteroid injection works better for shoulder tendonitis pain than the steroid alone. About 132 adults with confirmed supraspinatus tendinopathy will receive either the combo or a placebo injection. Pain levels ar…

This early study is testing whether metformin, a common diabetes medicine, can reduce pain and help heal chronic Achilles tendon problems. Forty people with long-term tendon pain will take either metformin or a placebo pill for 16 weeks, along with a home exercise program. Resear…

This study looks at whether doing a 12-week exercise program with your feet turned outward (toes-out) helps people with mid-portion Achilles tendinopathy more than the usual neutral-foot position. About 60 adults aged 18–65 with Achilles pain will be followed for 6 months. Resear…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether a needle-based electrical treatment (percutaneous electrolysis) or laser therapy works better for shoulder tendon pain. Forty adults with at least four weeks of symptoms will receive one treatment and be followed for a week. Researchers will measure pain,…

This study compares three methods to reduce pain during corticosteroid injections for arthritis, tendinopathy, or nerve compression in the hand, wrist, or elbow: no anesthesia, a vibrating device, or a cooling spray. Each participant will receive two of the three methods to see w…

This study will follow 10,000 adults with common joint or tendon problems—like knee arthritis, tennis elbow, or plantar fasciitis—who choose to receive a platelet-rich plasma (PRP) injection. PRP is made from a patient's own blood, spun to concentrate healing factors. Participant…

This study looks at 134 people with De Quervain's disease, a painful thumb tendon condition. All participants get a steroid injection, then either standard physiotherapy or a program of eccentric exercises. The goal is to see which approach better reduces pain and improves hand f…

This study tests whether using Doppler ultrasound to detect inflammation around calcium deposits in the shoulder can improve the results of a guided injection. 100 adults with chronic shoulder pain and calcific tendinitis will receive an ultrasound-guided injection, with or witho…

This study looks at whether adding a special needle treatment (low-intensity electrolysis) to standard exercises helps people with long-lasting Achilles tendon pain. About 102 adults with Achilles tendinopathy will receive either the real treatment or a sham version, plus exercis…

This study tests whether adding pulsed electromagnetic field (PEMF) therapy to standard physical therapy and spa treatments can reduce pain and improve shoulder function in people with chronic shoulder tendinopathy. Sixty adults aged 18 to 70 with shoulder pain lasting over 3 mon…

This early study tests a procedure called arterial embolization for people with long-lasting Achilles tendon pain that hasn't improved with other treatments. Doctors use a thin tube to inject a temporary blocking agent into small blood vessels around the tendon. Ten adults aged 2…

This study tests whether combining electroacupuncture with vacuum cupping therapy works better than electroacupuncture alone for shoulder tendinitis. Fifty-four adults with shoulder pain and stiffness will receive either electroacupuncture alone or electroacupuncture plus cupping…

This study tests a new exercise approach for people with long-term shoulder pain caused by rotator cuff problems. Instead of just doing standard shoulder exercises, participants will also perform movements that shift their focus away from the shoulder. The goal is to see if this …

This study looks at 108 adults who have hip tendon pain after a total hip replacement. It compares two different places to cut the tendon using a tiny camera and tools. The goal is to see which spot gives better pain relief and function over more than a year.

This study tests different physical therapy combinations for people with shoulder tendon pain (supraspinatus tendinitis). Researchers will measure pain, range of motion, and tendon thickness using ultrasound. 60 adults aged 40-60 with shoulder pain for up to 3 months will be assi…

This study looks at whether a quick session of electrical stimulation can lower pain and help people with Achilles tendon injuries move better. About 30 adults with Achilles tendinopathy or a past rupture will try two different stimulation methods. The goal is to see if this appr…

This study compares two exercise programs for people with long-term pain in the Achilles, patellar tendon, or plantar fascia. One group does standard strength training, while the other adds early jumping (plyometric) exercises. Researchers will measure jump function after 12 week…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available. The …

This study tests whether adding fascial manipulation to standard shock wave therapy improves pain and knee function in people with patellar tendinitis (jumper's knee). 38 adults aged 18-45 will be randomly assigned to receive either shock wave therapy alone or combined with targe…

This study tests whether adding shock wave therapy to a standard exercise program can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 30 to 55 with chronic shoulder pain will receive either exercises alone or exercises plus sh…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a minimally invasive procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with chronic shoulder pain from rotator cuff tendinopathy that hasn't improved with standard treatments. About 41 adults with moderate to sev…

This study tests whether adding an injection called Tropho Tend to standard physical therapy helps reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Sixty adults with shoulder pain lasting at least six weeks will be randomly assigned to receive e…

This study compares two ways of managing rotator cuff tendinopathy, a common cause of shoulder pain. One group gets monthly check-ups for three months with treatment adjustments as needed, while the other follows standard care. Researchers want to see if the tighter follow-up lea…

This study looks at how different types of electrical nerve stimulation affect leg strength in athletes with patellar tendinopathy (jumper's knee). Nineteen athletes will try three stimulation methods in separate sessions to see which one best improves quadriceps strength. The go…

This study tests whether a special laser (LightForce) can reduce shoulder pain caused by inflammation from conditions like impingement or rotator cuff tendinitis. About 130 adults with pain lasting over 3 months will get either real laser or a sham laser, plus standard physiother…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests a progressive exercise program for people with Achilles tendon pain, combined with education and clinician support. Researchers aim to find an effective rehab approach that improves access to care, especially for military personnel. The trial will enroll 160 adul…

This study tests whether blood flow restriction (BFR) training can reduce pain and improve elbow function in people with tennis elbow (lateral epicondylitis) who haven't gotten better with physical therapy. Forty adults will either receive BFR training or a sham treatment during …

This study looks at whether patients who feel more stressed before shoulder surgery for rotator cuff problems have a harder recovery. Researchers will measure stress levels in 100 adults using a questionnaire before their operation. The goal is to see if high stress is linked to …

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at whether a movement screening test can accurately detect changes in Achilles tendon pain in runners over 40. Forty senior runners with Achilles tendinopathy will be randomly assigned to two physiotherapy groups, one with extra stretching. The goal is to see if …

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study uses ultrasound to track how soft tissues like ligaments, tendons, and muscles stretch and move in different groups: baseball pitchers, people with ankle tendon problems, and patients recovering from ACL knee surgery. Researchers want to see if these measurements can h…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study is creating a new classification system for shoulder calcific tendinitis based on MRI scans. Researchers will look at 400 patients to see if the location of calcium deposits relates to which treatment works best. The goal is to help doctors choose between conservative …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at why exercise helps some people with shoulder pain from rotator cuff tendinopathy but not others. Researchers will use brain scans to see how exercise changes the brain and find out who is most likely to get better. The goal is to make exercise treatments more …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study tests a new, non-invasive ultrasound method called SURE to see the smallest blood vessels in tendons affected by overuse injuries (tendinopathy). Researchers will compare injured and healthy tendons in 135 adults to find differences in blood flow that could help diagno…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This observational study follows 100 people with tenosynovial giant cell tumor (TGCT) who are taking vimseltinib as part of their routine care. Researchers will collect data on how long patients stay on the drug and how it affects their quality of life. The study does not change …

This study follows up to 30 adults with tenosynovial giant cell tumor (TGCT) who had liver test abnormalities while taking TURALIO. The goal is to track long-term liver failure risk and understand how the drug may cause liver injury. Participants will be monitored after stopping …

This study tests whether starting gentle exercises with a special brace 3 weeks after peroneal tendon surgery leads to less pain and better function than the standard 6 weeks in a cast. Fifty adults in Sweden who have surgery for a torn peroneal tendon will be randomly assigned t…

This study will examine chest CT scans from 500 adults with rheumatoid arthritis, connective tissue diseases, or idiopathic pulmonary fibrosis to better understand lung disease patterns. Researchers want to see which scan features are most common in rheumatoid arthritis-related i…