Tendon sheath disorder

This phase 2 trial tests a daily oral drug called pimicotinib in 20 Japanese adults with tenosynovial giant cell tumor (TGCT) that cannot be removed by surgery. The study aims to see if the drug is safe, how it moves through the body, and whether it shrinks tumors. Participants t…

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the drugs pazopanib and selinexor to standard chemotherapy can improve outcomes. Participants receive treatment tailored to their…

This phase II trial is testing whether continuing targeted therapy or immunotherapy based on a tumor's molecular profile can benefit patients with advanced solid tumors that have stopped responding to prior treatment. After an initial treatment period, patients whose disease is s…

This trial compares two surgical methods for treating long head of the biceps tendon or SLAP lesions in people without full-thickness rotator cuff tears. One technique uses a self-locking mechanism, the other a 360 suture anchor. The goal is to see which provides better shoulder …

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the best dose, while also seeing if the drug can shrink…

This study tests whether a dye called indocyanine green (ICG) can help surgeons see tenosynovial giant cell tumors (TGCT) during surgery. About 40 people with TGCT will get an ICG injection before their operation. The dye makes tumor tissue glow under a special camera, which surg…

This study aims to create a new scoring system called HASS to reliably diagnose long biceps tendon injuries before surgery. Currently, these injuries are hard to confirm without surgery, leading to uncertainty. Researchers will combine physical exam tests and imaging data from 20…

This study compares two common treatments for trigger finger: shock wave therapy and a finger splint. Researchers will enroll 54 adults with early-stage trigger finger to see which approach better reduces pain and improves hand function. The goal is to find out if shock wave ther…

This study is testing a gel called OSTENIL TENDON to see if it safely reduces pain and improves movement in people with tendon problems. Researchers will enroll 84 adults with one of four types of tendinopathy. The main goal is to measure pain changes three months after treatment…

This study looks at 134 people with De Quervain's disease, a painful thumb tendon condition. All participants get a steroid injection, then either standard physiotherapy or a program of eccentric exercises. The goal is to see which approach better reduces pain and improves hand f…

This observational study follows 100 people with tenosynovial giant cell tumor (TGCT) who are taking vimseltinib as part of their routine care. Researchers will collect data on how long patients stay on the drug and how it affects their quality of life. The study does not change …

This study follows up to 30 adults with tenosynovial giant cell tumor (TGCT) who had liver test abnormalities while taking TURALIO. The goal is to track long-term liver failure risk and understand how the drug may cause liver injury. Participants will be monitored after stopping …