Disease of the tendon

This phase 3 trial tests the drug pexidartinib in 40 adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in joints that causes pain and limits movement. The study focuses on people whose tumors are severe and cannot be helped by surgery. Researchers are…

This study tests a drug called vimseltinib in people with a rare joint tumor (tenosynovial giant cell tumor, or TGCT) and advanced solid tumors. The drug blocks a protein that helps these tumors grow. The trial has two phases: first, finding the safest dose, then expanding to see…

This study is testing a special implant (Tapestry) that helps repair a key shoulder tendon (subscapularis) during shoulder replacement surgery. About 100 adults with shoulder arthritis or injury will be followed for 2 years to see if the tendon heals better with the implant. The …

This Phase 3 trial tests whether the drug Pimicotinib (ABSK021) can shrink tumors and improve symptoms in people with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in joints that cannot be surgically removed. About 94 adults will receive either the drug or a …

This phase 3 trial tests vimseltinib, an oral drug, for tenosynovial giant cell tumor (TGCT) when surgery isn't possible. About 123 adults with symptomatic TGCT will receive either vimseltinib or a placebo for 24 weeks, then all can get the drug. The main goal is to see if the dr…

This study compares two common injections—platelet-rich plasma (PRP) and corticosteroids—given during arthroscopic rotator cuff repair. 387 adults with full-thickness supraspinatus tears are randomly assigned to receive PRP, corticosteroid, or a placebo injection during surgery. …

This study tests an investigational drug called emactuzumab for people with a rare joint tumor (TGCT) that can't be removed surgically. About 128 participants will receive either the drug or a placebo to see if it shrinks tumors and improves joint function. The goal is to offer a…

This study tests a new injection called NEMO-103 to see if it makes shoulder MRI pictures clearer for diagnosing problems like torn tendons or cartilage. About 85 adults with known or suspected shoulder issues will get both a regular MRI and one with the injection. The goal is to…

This study compares two 12-week exercise programs—eccentric training and heavy-slow resistance training—in 30 adults aged 18–50 with patellar tendinopathy (knee pain lasting over 3 months). Researchers measure changes in tendon thickness, stiffness, strength, and pain to see whic…

This study compares three non-surgical treatments—exercise therapy, shockwave therapy, and ultrasound-guided irrigation—against a wait-and-see approach for people with painful calcium deposits in the shoulder. About 116 participants with confirmed calcific tendinopathy will be ra…

This study compares physical therapy delivered through video calls to traditional in-person therapy for 50 young elite baseball players with rotator cuff problems. The goal is to see if remote therapy is as effective at improving shoulder function and reducing pain, and whether i…

This study tests whether giving people with rotator cuff shoulder pain regular updates on their progress (like pain scores and strength) helps them recover better. 56 adults aged 18–35 will either get standard rehab or standard rehab plus these progress updates. The goal is to se…

This study tests whether using virtual reality and action observation therapy during the time a wrist or hand is in a cast can improve recovery. Participants watch first-person videos of hand movements through a VR headset and then practice those movements. The goal is to prevent…

This study tests whether a specific type of exercise called eccentric contraction (lengthening muscles under tension) can help people with shoulder pain syndrome. Sixty adults aged 18-70 with rotator cuff tendinitis will do either eccentric exercises plus standard therapy or stan…

This study tests whether adding yellow or green light therapy to standard care (ice and exercises) can reduce pain and improve knee function in 60 athletes with jumper's knee. Participants will receive either yellow light, green light, or standard care alone. The goal is to see i…

This study compares two surgical techniques for treating various Achilles tendon disorders, such as chronic tears and tendinopathy. One method uses a small camera (endoscopic) and the other uses a larger open incision. The goal is to see which approach leads to better function, f…

This study looks at whether a treatment called pulsed radiofrequency (PRF) applied to a key shoulder nerve can help people with long-lasting shoulder pain that hasn't improved with standard treatments like painkillers or physical therapy. The study involves 60 adults with chronic…

This study aimed to see if a 12-week resistance training program could improve tendon health in people with Achilles tendinopathy, a condition causing pain and swelling in the Achilles tendon. Researchers planned to enroll at least 20 patients who would perform daily exercises th…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This study looks at whether adding deep friction massage to a standard exercise program helps people with bicipital tendinitis (a painful shoulder condition). Researchers will measure pain, movement ability, fear of movement, and quality of life in 42 adults aged 20-55. The goal …

This study aimed to test a new exercise program for people with shoulder impingement syndrome, a common cause of shoulder pain. The program involved progressive resistance exercises over 14 weeks. However, the trial was withdrawn before enrolling any participants, so no data or c…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests whether a self-management program led by a physiotherapist can reduce pain and improve function in people with greater trochanteric pain syndrome (chronic hip pain). 110 adults aged 18-70 with hip pain for over 3 months will be randomly assigned to either the sel…

This pilot study aimed to compare a single injection of connective tissue matrix (CTM) against a standard corticosteroid shot for treating rotator cuff tendinopathy. Participants would have been randomly assigned to one of the two injections and followed for six months with quest…

This study tests if a biceps tendon cutting procedure (tenotomy) done in the doctor's office with a tiny camera and local anesthesia works as well as the same surgery in an operating room. 14 adults with shoulder pain from biceps or rotator cuff problems will be enrolled. The mai…

This study compares two ways to treat new Achilles tendon pain: doing exercises at home versus going to a physical therapist. About 56 adults with Achilles tendinopathy will be randomly assigned to one of the two groups for 12 weeks. Researchers will track pain, function, and moo…

This study looks at whether strengthening the latissimus dorsi muscle can improve shoulder space, reduce pain, and boost function in people with rotator cuff tendinopathy. 47 adults aged 18-50 with ongoing shoulder pain will be split into three groups: rotator cuff exercises only…

This study compares two types of injections for people with shoulder pain caused by rotator cuff tendinopathy. One injection, CTM Boost, is made from donated placental tissue, and the other, PRP, uses a patient's own blood. The goal is to see if CTM Boost works as well as PRP at …

This study follows 50 adults who had surgery for a broken shinbone to see if changes in the kneecap tendon's stiffness relate to knee pain. Researchers use a special ultrasound before and up to 6 months after surgery. The goal is to better understand why some people develop front…

This study looks at how the position and angle of surgical anchors used in rotator cuff repair affect cyst formation and tendon healing. Researchers will use MRI scans to measure cyst volume and assess tendon recovery in 70 adults aged 18–70 undergoing primary arthroscopic repair…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study was designed to compare two standard surgical techniques for bicep tenodesis—using one anchor or two mini anchors—to see which keeps the tendon in place better. It planned to track tendon movement with X-rays right after surgery, at 2 weeks, and at 6 months. However, t…

This study looks at how well a bioimplant helps heal hip tendons after surgery. Fifteen adults with torn gluteal tendons will get the implant during standard repair. Researchers will use ultrasound and questionnaires to check tissue healing and hip function over time.

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study planned to compare waterproof and standard casts in children with ankle or foot injuries. The goal was to see if waterproof casts lead to more complications. However, the study was withdrawn before enrolling any participants, so no data or conclusions are available.