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Can talk therapy rewire the brain to ease burn Survivors' pain?

NCT ID NCT07824635

Symptom relief Sponsor: Spaulding Rehabilitation Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Many burn survivors live with persistent pain that disrupts daily life, and negative thoughts about pain can make it worse. Researchers are testing an 8-week cognitive behavioral therapy program delivered by video to see if it reduces pain interference and pain catastrophizing more than an 8-week pain education program. The study enrolls 92 adults who were hospitalized for a burn injury and still have burn-related pain. Brain scans before and after treatment aim to show how this non-drug approach changes pain processing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive behavioral therapy delivered by video
What this could lead to
If it works, this could give burn survivors a remote, non-drug way to reduce how much pain disrupts daily life. It could also show which brain changes accompany that relief.
What could go wrong
The trial is small and compares therapy with pain education, so any benefit may be modest or hard to separate from extra attention. Brain scan findings may not translate into lasting pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 92 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Oct 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previously hospitalized for burn injury * Age 18 to 65 years * Able to provide written informed consent and fluent in English * Living in a community setting * Six (6) months or more post-burn injury * Burn-related pain rated as ≥4 (on a scale of 0-10) over the past week, co-localized with the site of the burn injury Exclusion Criteria: * Comorbid acute pain condition. * Comorbid chronic pain condition that is rated by the participant as more painful than the burn injury pain. * Living in an institution or medical facility. * Pregnant or nursing. * Any psychiatric condition precluding study participation, such as a disorder involving psychosis (e.g., schizophrenia), unmanaged bipolar disorder, or a severe personality disorder. * History of anxiety disorders or significant anxiety symptoms interfering with imaging procedures (e.g., panic). * Contraindication to MRI (e.g., implanted ferrous metal). * History of significant head injury (e.g., with substantial loss of consciousness). * Psychiatric hospitalization in the past 6 months. * Currently participating in therapeutic clinical research trials.

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Conditions

The condition(s) this trial relates to.

burn Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burn Chronic pain Pain catastrophizing

How to take part

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  1. The official record

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