Freezing pain: new study tests if nerve blocks can predict cryoneurolysis success

NCT ID NCT07289984

Not yet recruiting Knowledge-focused Sponsor: Universitair Ziekenhuis Brussel Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a diagnostic nerve block can predict how well cryoneurolysis—a procedure that uses extreme cold to temporarily freeze nerves—will work for people with long-term muscle and bone pain. Researchers will enroll 50 adults with chronic pain and measure pain levels and walking ability before and after treatment. The goal is to see if the nerve block response matches the cryoneurolysis outcome, which could help personalize pain treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoneurolysis (a procedure using extreme cold to temporarily block nerves)
What this could lead to: If successful, this could help doctors identify which patients will benefit from cryoneurolysis, improving pain management for chronic musculoskeletal pain.
What could go wrong: This is an early observational study with only 50 participants, so results may not apply to everyone. The procedure itself carries risks like nerve damage or incomplete pain relief.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MUSCULOSKELETAL PAIN CRYO ANALGESIA CRYOABLATION SPASTICITY

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