Could freezing nerves beat botox for spastic shoulder pain?

NCT ID NCT06782464

Recruiting now Disease control Sponsor: Centre National de Rééducation Fonctionnelle et de Réadaptation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injections, then follow a 24-week rehab program. The goal is to see if the freezing treatment works as well as Botox and lasts longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoneurolysis (nerve freezing)
What this could lead to: If it works, this could offer a longer-lasting alternative to Botox for shoulder pain and stiffness caused by spasticity, reducing the need for repeat injections.
What could go wrong: This is a small, early-stage trial with only 50 participants. The procedure is new for this use, and it may not work as well as expected or could have unknown side effects.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic hemiplegia multiple sclerosis Muscle Spasticity Pain spastic hemiplegia spinal cord injury stroke disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMIPLEGIA MULTIPLE SCLEROSIS SHOULDER SPASTICITY SHOULDER STIFFNESS SPASTICITY SPINAL CORD INJURY STROKE TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Rehazenter, Centre National de Rééducation fonctionnelle et de Réadaptation
RECRUITING

Luxembourg, 2674, Luxembourg

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