Silent artery disease exposed: 16,000-Person study aims to predict heart attacks before they happen
NCT ID NCT06692127
First seen Jul 13, 2026 · Last updated Jul 15, 2026 · Updated 2 times
Summary
This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, and biomarkers to predict who will develop heart disease. Ultimately, this knowledge could lead to earlier, more personalized prevention strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple screening tool that identifies people with hidden artery disease years before a heart attack or stroke, enabling early prevention.
- What could go wrong
- This is an observational study, not a treatment trial. The risk calculator will need further testing before it can be used in routine care, and it may not work equally well for all populations.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Madrid, E-28029, Spain
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Herlev Hospital
Herlev, 2730, Denmark
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Regionshospitalet Gødstrup
Herning, 7400, Denmark
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Righospitalet - Glostrup Hospital
Glostrup Municipality, 2600, Denmark
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Rigshospitalet
Copenhagen, 2100, Denmark
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