ATHEROSCLEROSIS

This international study is testing whether using just one blood-thinning medication is as safe and effective as using two after a specific type of heart artery procedure. It focuses on patients aged 75 and older or those at high risk for bleeding. The goal is to find the best ba…

This study is testing a new injectable drug, IMC-001, to see if it can safely reduce the volume of a dangerous type of soft plaque in the heart arteries of patients who recently had a heart attack or unstable angina. The trial will enroll 30 participants who are already receiving…

This study is testing whether an 8-week mindfulness and stress reduction program can reduce inflammation in the arteries of people with stable heart disease. Researchers will use PET and MRI scans to measure artery inflammation before and after the program in 36 adults who report…

This large Phase 3 trial is testing whether adding two common medications to standard care can prevent future strokes, heart attacks, and other major vascular problems in high-risk patients who have recently had a stroke. It will compare a low-dose anti-inflammatory drug (colchic…

This study is testing whether an experimental drug called ziltivekimab can reduce inflammation in the arteries of people with heart disease. Researchers will give the drug or a placebo to 40 patients for 20 weeks and use advanced scans and blood tests to see if it lowers inflamma…

This small pilot study is testing whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel highly stressed. About 30 participants will be randomly assigned to either learn mindfulness and relaxation techniques or receive no interventio…

This study is testing whether a medication called bempedoic acid can help reduce heart disease risk in people living with HIV. Researchers want to see if the drug lowers cholesterol, reduces artery inflammation, and improves heart health markers. The trial involves 121 HIV-positi…

This study is developing a smartphone app that uses artificial intelligence (AI) to help doctors interpret sounds from a handheld artery 'stethoscope'. Researchers will collect sound recordings from 180 patients who need routine artery testing and compare the AI's analysis to sta…

This study is testing a new prevention strategy for people who go to the emergency room with chest pain but are not having a heart attack. Researchers want to see if using a special heart scan (calcium score) and a follow-up PET scan can find unstable plaque in the arteries, whic…

This study is testing a new program that starts heart disease prevention for patients visiting the emergency room for chest pain. The program checks cholesterol, calculates heart risk, and prescribes medication right away, with the goal of preventing future heart attacks and stro…

This large VA study is testing whether metformin, a common diabetes medication, can prevent heart attacks, strokes, and death in veterans who have pre-diabetes and existing heart or blood vessel disease. Over 7,400 participants will receive either metformin or a placebo pill, alo…

This study aims to understand why heart disease develops differently in women and men, focusing on the roles of hormones and inflammation. Researchers will collect blood samples and survey 6000 patients with chest pain to analyze hormone levels and inflammatory markers. The goal …

This study aims to learn more about rare and poorly understood diseases that affect the heart and blood vessels. Researchers will enroll up to 5,000 people, including patients, their relatives, and healthy volunteers, to collect medical data, images, and samples. The goal is to i…

This study aims to understand how a person's genes affect how their immune cells respond to potential threats. Researchers will collect blood from healthy volunteers to grow immune cells in a lab and test their reactions. The goal is to learn if certain genetic patterns make peop…

This study aims to learn which advanced imaging techniques lead to the best long-term results for patients with clogged heart arteries. Researchers will follow 2,000 adults who have had a standard heart artery scan and an additional, more detailed scan. The goal is to see if usin…

This study aims to better understand how disorders of blood fats (like cholesterol) develop over time and contribute to heart and blood vessel diseases. Researchers will observe and perform detailed blood tests on up to 2,000 people who have unusually high or low levels of these …

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This study aims to better understand rare, often inherited disorders that cause abnormal levels of fats like cholesterol in the blood. Researchers will observe how these conditions change over many years and how patients respond to their regular treatments. The goal is to gather …