New drug YN001 aims to shrink artery plaque in heart disease trial

NCT ID NCT07521007

Recruiting now Disease control Sponsor: Beijing Inno Medicine Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a special CT scan. The trial is not yet recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: YN001 (a drug given by injection)
What this could lead to: If it works, this could point toward a new treatment to reduce artery plaque and better manage heart disease.
What could go wrong: This is an early Phase 2b trial, so it may not show clear benefit. The drug could have side effects, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary artery disorder coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS CORONARY ARTERY DISEASE

Contacts and locations

Locations

Anhui Provincial Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230001, China
Anzhen Hospital
RECRUITING

Beijing, Beijing Municipality, 100029, China
Beijing Jishuitan Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100035, China
Cannopy Clinical Research
NOT_YET_RECRUITING

Penrith, New South Wales, 2750, Australia
Canopy Clinical Research
NOT_YET_RECRUITING

Altona N., Victoria, 3025, Australia
Capital Area Research
NOT_YET_RECRUITING

Camp Hill, Pennsylvania, 17011, United States
Clinical Trials Research
NOT_YET_RECRUITING

Lincoln, California, 95648, United States
Excel Medical Clinical Trials dba Flourish Research - Boca Raton
NOT_YET_RECRUITING

Boca Raton, Florida, 33434, United States
Fudan University-Zhongshan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Medical University Union Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350001, China
HCA Florida Heart Institute
NOT_YET_RECRUITING

Petersburg, Florida, 33709, United States
Heart Center Research, LLC
NOT_YET_RECRUITING

Huntsville, Alabama, 35801, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NOT_YET_RECRUITING

Torrance, California, 90502, United States
Midwest Heart & Vascular Specialists
NOT_YET_RECRUITING

Overland Park, Kansas, 66209, United States
North York Diagnostic and Cardiac Center
NOT_YET_RECRUITING

North York, Ontario, M6B 3H7, Canada
Renji Hospital Shanghai Jiaotong University school of medicine
RECRUITING

Shanghai, Shanghai Municipality, 200001, China
Southern Illinois University School of Medicine
NOT_YET_RECRUITING

Springfield, Illinois, 62781, United States
Stanford University School of Medicine
NOT_YET_RECRUITING

Stanford, California, 94305, United States
The Carl & Edyth Lindner Center for Research & Education at The Christ Hospital
NOT_YET_RECRUITING

Cincinnati, Ohio, 45219, United States
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150001, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130033, China
The People's Hospital of Liaoning Province
RECRUITING

Shenyang, Liaoning, 110015, China
The Second Hospital of Tianjin Medical University
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300211, China
Tianjin People's Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300121, China
Wake Forest University Health Sciences
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Zhongnan Hospital of Wuhan University
RECRUITING

Wuhan, Hubei, 430071, China

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