New drug YN001 aims to shrink artery plaque in heart disease trial
NCT ID NCT07521007
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a special CT scan. The trial is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
YN001 (a drug given by injection)
What this could lead to
If it works, this could point toward a new treatment to reduce artery plaque and better manage heart disease.
What could go wrong
This is an early Phase 2b trial, so it may not show clear benefit. The drug could have side effects, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Anhui Provincial Hospital
Hefei, Anhui, 230001, China
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Anzhen Hospital
Beijing, Beijing Municipality, 100029, China
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Beijing Jishuitan Hospital
Beijing, Beijing Municipality, 100035, China
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Fudan University-Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China
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Fujian Medical University Union Hospital
Fuzhou, Fujian, 350001, China
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Renji Hospital Shanghai Jiaotong University school of medicine
Shanghai, Shanghai Municipality, 200001, China
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The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
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The First Hospital of Jilin University
Changchun, Jilin, 130033, China
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The People's Hospital of Liaoning Province
Shenyang, Liaoning, 110015, China
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The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, 300211, China
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Tianjin People's Hospital
Tianjin, Tianjin Municipality, 300121, China
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West China Hospital of Sichuan University
Chengdu, Sichuan, 610041, China
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Zhongnan Hospital of Wuhan University
Wuhan, Hubei, 430071, China
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