New drug aims to shrink Heart-Artery plaque in major trial

NCT ID NCT07521007

First seen Apr 09, 2026 · Last updated May 07, 2026 · Updated 1 time

Summary

This study tests an experimental drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants will receive either YN001 or a placebo by IV, alongside their usual heart medications. The main goal is to see if YN001 reduces non-calcified plaque volume in the arteries after 13 weeks, as measured by CT scan.

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Contacts and locations

Study contacts

  • Contact

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Locations

  • Anhui Provincial Hospital

    Hefei, Anhui, 230001, China

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  • Anzhen Hospital

    Beijing, Beijing Municipality, 100029, China

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  • Beijing Jishuitan Hospital

    Beijing, Beijing Municipality, 100035, China

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  • Fudan University-Zhongshan Hospital

    Shanghai, Shanghai Municipality, 200032, China

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

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  • Renji Hospital Shanghai Jiaotong University school of medicine

    Shanghai, Shanghai Municipality, 200001, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001, China

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  • The First Hospital of Jilin University

    Changchun, Jilin, 130033, China

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  • The People's Hospital of Liaoning Province

    Shenyang, Liaoning, 110015, China

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  • The Second Hospital of Tianjin Medical University

    Tianjin, Tianjin Municipality, 300211, China

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  • Tianjin People's Hospital

    Tianjin, Tianjin Municipality, 300121, China

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  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 610041, China

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  • Zhongnan Hospital of Wuhan University

    Wuhan, Hubei, 430071, China

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