Common diabetes drug tested to save hearts in Pre-Diabetes

NCT ID NCT02915198

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The goal is to see if metformin can help control the disease and prevent serious cardiovascular events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin (extended-release)
What this could lead to: If it works, this could show that metformin helps prevent major heart problems in people with pre-diabetes and existing heart disease.
What could go wrong: This is a large Phase 4 trial, but metformin is already widely used for diabetes. It may not provide additional heart benefits for pre-diabetes, and some people may experience digestive side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease cerebrovascular disorder coronary artery disorder peripheral arterial disease prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS METFORMIN PREDIABETIC STATE

Contacts and locations

Locations

Atlanta VA Medical and Rehab Center, Decatur, GA
RECRUITING

Decatur, Georgia, 30033-4004, United States
Bay Pines VA Healthcare System, Pay Pines, FL
RECRUITING

Bay Pines, Florida, 33744-0000, United States
Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR
RECRUITING

Little Rock, Arkansas, 72205-5484, United States
Cincinnati VA Medical Center, Cincinnati, OH
ACTIVE_NOT_RECRUITING

Cincinnati, Ohio, 45220-2213, United States
Clement J. Zablocki VA Medical Center, Milwaukee, WI
RECRUITING

Milwaukee, Wisconsin, 53295-0001, United States
Durham VA Medical Center, Durham, NC
RECRUITING

Durham, North Carolina, 27705-3875, United States
Edward Hines Jr. VA Hospital, Hines, IL
RECRUITING

Hines, Illinois, 60141-3030, United States
Hunter Holmes McGuire VA Medical Center, Richmond, VA
RECRUITING

Richmond, Virginia, 23249, United States
Huntington VA Medical Center, Huntington, WV
RECRUITING

Huntington, West Virginia, 25704-9300, United States
Iowa City VA Health Care System, Iowa City, IA
RECRUITING

Iowa City, Iowa, 52246-2292, United States
Jesse Brown VA Medical Center, Chicago, IL
TERMINATED

Chicago, Illinois, 60612, United States
Kansas City VA Medical Center, Kansas City, MO
RECRUITING

Kansas City, Missouri, 64128-2226, United States
Lexington VA Medical Center, Lexington, KY
NOT_YET_RECRUITING

Lexington, Kentucky, 40502-2235, United States
Louis Stokes VA Medical Center, Cleveland, OH
RECRUITING

Cleveland, Ohio, 44106-1702, United States
Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY
RECRUITING

New York, New York, 10010-5011, United States
Memphis VA Medical Center, Memphis, TN
RECRUITING

Memphis, Tennessee, 38104-2127, United States
Miami VA Healthcare System, Miami, FL
RECRUITING

Miami, Florida, 33125, United States
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITING

Houston, Texas, 77030-4211, United States
Minneapolis VA Health Care System, Minneapolis, MN
RECRUITING

Minneapolis, Minnesota, 55417-2309, United States
New Mexico VA Health Care System, Albuquerque, NM
RECRUITING

Albuquerque, New Mexico, 87108-5153, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL
RECRUITING

Gainesville, Florida, 32608-1135, United States
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
RECRUITING

Omaha, Nebraska, 68105-1850, United States
Phoenix VA Health Care System, Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85012, United States
Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITING

Charleston, South Carolina, 29401-5703, United States
Rehabilitation R&D Service, Baltimore, MD
RECRUITING

Baltimore, Maryland, 21202, United States
Rocky Mountain Regional VA Medical Center, Aurora, CO
RECRUITING

Aurora, Colorado, 80045-7211, United States
Salem VA Medical Center, Salem, VA
RECRUITING

Salem, Virginia, 24153-6404, United States
Southern Arizona VA Health Care System, Tucson, AZ
RECRUITING

Tucson, Arizona, 85723-0001, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
RECRUITING

Boston, Massachusetts, 02130-4817, United States
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
RECRUITING

West Haven, Connecticut, 06516-2770, United States
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
RECRUITING

West Los Angeles, California, 90073-1003, United States
VA Loma Linda Healthcare System, Loma Linda, CA
RECRUITING

Loma Linda, California, 92357-1000, United States
VA Long Beach Healthcare System, Long Beach, CA
RECRUITING

Long Beach, California, 90822, United States
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
RECRUITING

Dallas, Texas, 75216-7167, United States
VA Pacific Islands Health Care System, Honolulu, HI
RECRUITING

Honolulu, Hawaii, 96819-1522, United States
VA Palo Alto Health Care System, Palo Alto, CA
RECRUITING

Palo Alto, California, 94304-1207, United States
VA Portland Health Care System, Portland, OR
RECRUITING

Portland, Oregon, 97207-2964, United States
VA Salt Lake City Health Care System, Salt Lake City, UT
RECRUITING

Salt Lake City, Utah, 84148-0001, United States
VA San Diego Healthcare System, San Diego, CA
RECRUITING

San Diego, California, 92161-0002, United States
Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC
RECRUITING

Columbia, South Carolina, 29209-1638, United States

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