PREDIABETIC STATE

This study tests whether applying heat pads to the legs for 90 minutes a day can improve blood sugar control, muscle health, and physical function in older adults with prediabetes. Researchers will compare the effects to high-intensity interval training. The goal is to find a sim…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This study tests whether exercising in the afternoon is better than the morning for improving blood sugar control in people with prediabetes. 48 participants will do high-intensity interval training three times a week for 12 weeks. Researchers will measure how the body stores and…

This study tests whether taking a daily 30 mg zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Two hundred Amish adults aged 18–80 with prediabetes will be randomly assigned to receive either zinc or a placebo pill. Researchers will …

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This pilot study tests whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program (DPP) helps recruit and keep participants engaged. Twenty adults with prediabetes from two community health centers in Los Angeles will take part. The main goal is …