PREDIABETIC STATE

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study looks at whether treating insomnia with cognitive behavioral therapy (CBT-I) can lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either receive CBT-I or a general health education program. The goal is to see…

This study tests whether applying heat pads to the legs can improve muscle health, physical function, and blood sugar control in older adults with prediabetes. Researchers will compare heat therapy to high-intensity interval training (HIIT) and see if heat can prepare muscles for…

This study looks at whether adding hands-on cooking and nutrition lessons can help people at risk for prediabetes stick with a diabetes prevention program. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and helpful for keeping part…

This study looks at whether the diabetes drug metformin can lower the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will take metformin or a placebo and be followed for years. T…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study aims to find early signs that predict memory loss and dementia in 850 older adults, including those with mild memory issues or prediabetes. Researchers will track thinking skills, brain scans, and spinal fluid markers over time. The goal is to better understand how pro…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study looks at whether resistance training (like lifting weights) can improve how fat is broken down in obese postmenopausal women who have prediabetes. Researchers will measure fat metabolism before and after 12 weeks of training. The goal is to find a practical way to prev…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. They will measure insulin sensitivity, fitness, and overall health to understa…