New drug aims to quiet artery inflammation and prevent heart attacks

NCT ID NCT07448038

Recruiting now Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. The goal is to see if selnoflast can reduce inflammation inside the arteries, measured by a special PET scan, compared to a placebo. All participants continue their standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: selnoflast
What this could lead to: If it works, this could point toward a new way to lower inflammation in arteries and reduce the risk of heart attacks or strokes in people with atherosclerosis.
What could go wrong: This is an early Phase 2 trial with only 162 participants, so results may not apply to everyone. The drug may not reduce inflammation enough or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS

Contacts and locations

Locations

Ahmed Arif Medical Research Center (AA MRC LLC )
RECRUITING

Flint, Michigan, 48504, United States
Alliance Clinical West Hills (Focus Clinical Research)
RECRUITING

West Hills, California, 91307, United States
Amnova Clinical Research
RECRUITING

Irvine, California, 92604, United States
Asha Clinical Research-Munster,Llc
RECRUITING

Hammond, Indiana, 46324, United States
Cardio Health Clinical Trials
RECRUITING

Hamilton, Ontario, L8W 3K5, Canada
Cardiovascular Research Foundation of Southern California
RECRUITING

Beverly Hills, California, 90210, United States
Cardiovascular Specialists of Willowbrook
RECRUITING

Houston, Texas, 77070, United States
DiGiovanna Inst for Med Ed&Res
RECRUITING

North Massapequa, New York, 11758-1802, United States
East Texas Cardiology PA
RECRUITING

Houston, Texas, 77002, United States
Eastside Research Associates, LLC dba Era Health Research
RECRUITING

Redmond, Washington, 98036, United States
Inpatient Research Clinic (Las Palmas Medical Research Center)
RECRUITING

Miami Lakes, Florida, 33014, United States
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States
Preferred Primary Care Physicians, Inc
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States
Profound Research LLC at Cardiology and Vascular Associates - CAVA
RECRUITING

Bloomfield Hills, Michigan, 48304, United States
Profound Research LLC at Millenium Cardiology
RECRUITING

Farmington Hills, Michigan, 48334, United States
Southwest Family Medicine Associates
RECRUITING

Dallas, Texas, 75235, United States

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