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Aged heart cells may hold clues to heart disease progression after attack

NCT ID NCT07693712

Knowledge-focused Sponsor: South Tees Hospitals NHS Foundation Trust Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at whether heart cells that age rapidly after a heart attack release harmful proteins that make heart disease worse. Researchers will collect blood and heart tissue samples from people undergoing coronary artery bypass surgery after a recent heart attack or for stable heart disease. The goal is to see if these aged-cell proteins can help predict who is at highest risk of further heart problems and how well people recover.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify which patients are at highest risk of worsening heart disease after a heart attack, potentially guiding more personalized treatment.
What could go wrong
This is a small, early-stage observational study with only 22 participants, so findings may not apply to all heart attack patients. It aims to understand biology, not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

22 people

The number who actually took part.

Started

May 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population are male and female patients undergoing CABG surgery. There will be 70 patients split between two groups of 35 patients each. Group I will be patients who are undergoing coronary artery bypass graft surgery for recent Non-ST segment elevation myocardial infarction (NSTEMI), and Group II will be patients undergoing CABG for stable coronary artery disease

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female patients aged 40 to 80 years old undergoing coronary artery bypass graft surgery for myocardial infarction or for stable angina. Exclusion Criteria: * patients with ST-elevation myocardial infarction requiring coronary angioplasty * patients who have had previous cardiac surgery * patients who have evidence of ongoing heart failure, * a left ventricular ejection fraction of less than 30% * need for pre-operative mechanical cardiac support. * Individuals with pre-existing acute kidney injury * Sepsis * \>Stage 4 chronic kidney disease

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder coronary artery disorder heart failure Inflammation inflammatory disease myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Atherosclerosis Cardiovascular diseases Coronary artery disease Heart failure Inflammation Myocardial infarction

Contacts and locations

Locations

  • South Tees Hospitals NHS Foundation Trust

    Middlesbrough, TS4 3BW, United Kingdom

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