Can an Hourglass-Shaped device relieve chest pain when arteries Aren't blocked?

NCT ID NCT05492110

Ongoing Disease control Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. The study will compare the device to a sham procedure and measure changes in heart blood flow and symptoms over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Coronary sinus reducer device
What this could lead to: If effective, this device could offer a new treatment option for people with angina who have no blocked arteries, improving their symptoms and quality of life.
What could go wrong: This is a small pilot study, so results may not be definitive. The procedure is invasive and carries risks, and the device may not improve symptoms for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANGINA PECTORIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Angina Pectoris Chest Pain coronary artery disorder Coronary Disease coronary microvascular disorder intermediate coronary syndrome Microvascular Angina nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGINA PECTORIS ANOCA - ANGINA WITH NON-OBSTRUCTIVE CORONARY ARTERIES CORONARY DISEASE CORONARY MICROVASCULAR DYSFUNCTION (CMD) INOCA (ISCHEMIA WITH NON OBSTRUCTIVE CORONARY ARTERY DISEASE) MICROVASCULAR ANGINA MICROVASCULAR CORONARY ARTERY DISEASE REFRACTORY ANGINA

Contacts and locations

Locations

National Heart and Lung Institute (Brompton Campus), Imperial College London

London, London, SW36NP, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.