Can a diabetes drug unclog the Heart's tiny vessels?

NCT ID NCT07741890

Not yet recruiting Disease control Sponsor: The Christ Hospital Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study measures changes in heart blood flow using MRI scans, and also looks at heart tissue health and structure. The goal is to see if this drug can ease symptoms and improve heart function in this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dapagliflozin (10 mg tablet) taken daily for 180 days, compared against a placebo.
What this could lead to: If it works, dapagliflozin could become a new treatment option to ease chest pain and improve heart blood flow in people with angina caused by tiny vessel dysfunction, not blocked arteries.
What could go wrong: This is an early phase 2 trial with 120 participants, so results may not hold up in larger studies. Dapagliflozin can cause side effects like dehydration, urinary infections, or low blood sugar, and it may not improve symptoms for everyone.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGINA WITH NON-OBSTRUCTIVE CORONARY ARTERY DISEASE CORONARY MICROVASCULAR DYSFUNCTION (CMD)

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