Could a blood pressure drug ease chest pain in people with clear arteries?
NCT ID NCT07670091
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and after. The goal is to understand if this approach could lead to new treatments for microvascular angina.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bosentan (endothelin receptor antagonist)
- What this could lead to
- If it works, this could point toward a new treatment for angina caused by small vessel problems, not just blocked arteries.
- What could go wrong
- This is a very small, early study (45 people) looking at blood flow changes, not symptoms. Bosentan may not improve angina or could have side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NHS University Hospitals of Liverpool Group
Liverpool, United Kingdom
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