CORONARY DISEASE

This study tests whether doing repeated cycles of brief arm blood-flow restriction (remote ischemic preconditioning) over several months can improve blood flow to the heart muscle in people who have had coronary artery bypass grafting. Researchers will measure heart perfusion at …

This study looks at people who recently had a major heart attack (STEMI) and have multiple blocked arteries. Doctors want to see if placing stents in unstable-looking plaques (that aren't severely blocking blood flow) plus medication is better than medication alone to prevent fut…

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in everyday medical practice. About 2000 adults with coronary artery disease will receive these stents to open blocked arteries. Researchers will track deaths, heart attacks, and the nee…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study compares two methods to treat hardened (calcified) blockages in heart arteries that branch. Half of the 200 participants will get standard balloon treatment before a stent, while the other half will get a special device called an orbital atherectomy to first remove som…

This study watches 1,000 adults who get the DESyne X2 stent for blocked heart arteries. It tracks serious events like death, heart attack, or repeat procedures over time. The goal is to see how safe and effective the stent is in routine hospital use.

This study compares two non-invasive heart tests—stress echocardiography (ultrasound) combined with a neck artery scan versus a standard CT scan—to see which better detects blocked arteries and prevents heart attacks or other serious events. About 2,000 people with suspected coro…

This study is looking at 10,000 young adults (ages 18-45) with early signs of heart disease to understand how their condition changes over time. Researchers will use CT scans and health information to build a model that predicts who is at risk for worsening heart disease. The goa…

This study looks at a simpler method to check if heart artery treatments worked well. Instead of using a drug that can cause side effects, doctors will use a special wire and nitroglycerin to measure blood flow. About 150 people with blockages in multiple heart arteries will take…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these new techniques are accurate and can help predict future heart problems. About 5,000 adults who need a heart CT scan will participate. Th…