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Heart attack aftermath: new imaging method may spot hidden danger zones better than standard tests

NCT ID NCT05027984

Ongoing Disease control Sponsor: Centro per la Lotta Contro l'Infarto - Fondazione Onlus Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants will be randomly assigned to one of the two methods. The goal is to see which approach better prevents future heart-related deaths or heart attacks in the treated arteries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Optical coherence tomography (OCT) imaging and physiology-based measurements (iFR/FFR/RFR) to guide treatment decisions
What this could lead to
If successful, this could establish a more precise way to identify dangerous artery plaques, potentially preventing future heart attacks and deaths in patients who have already had one.
What could go wrong
The trial is large but still experimental; the OCT-guided approach may not prove better than standard physiology-guided care, and there are risks from additional imaging or unnecessary stenting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome coronary artery disorder Coronary Disease myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE CORONARY DISEASE ISCHEMIC HEART DISEASE

Contacts and locations

Locations

  • ARNAS Brotzu

    Cagliari, CA, 09047, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, BG, 24127, Italy

  • Azienda Ospedaliera "Policlinico "G. Rodolico- San Marco"

    Catania, CT, 95123, Italy

  • Azienda Ospedaliera Per L'emergenza Cannizzaro

    Catania, CT, 95126, Italy

  • Azienda Ospedaliera San Pio

    Benevento, BN, 82100, Italy

  • Azienda Ospedaliero Universitaria Policlinico "G. Martino", Messina

    Messina, ME, 98124, Italy

  • Azienda Ospedaliero_Universitaria IRCCS Policlinico di St.Orsola

    Bologna, BO, 40138, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale - Udine University Hospital

    Udine, UD, 33100, Italy

  • Centro Cardiologico Monzino IRCCS

    Milan, MI, 20138, Italy

  • Di Venere Hospital

    Bari, BA, 70131, Italy

  • Ente ecclesiastico Ospedale Regionale Generale "F. Miulli"

    Acquaviva delle Fonti, BA, 70021, Italy

  • Federico II di Napoli

    Naples, 80138, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Roma, RM, 00168, Italy

  • Hospital Universitario Central de Asturias

    Oviedo, 33011, Spain

  • Hospital Virgen de la Victoria

    Málaga, MA, 29010, Spain

  • Hospital universitario La Princesa, Madrid

    Madrid, M, 28006, Spain

  • IRCCS Casa sollievo della sofferenza

    San Giovanni Rotondo, FG, 71013, Italy

  • IRCCS Galeazzi- Sant'Ambrogio

    Milan, MI, 20157, Italy

  • IRCCS Ospedale Policlinico San Martino

    Genova, GE, 16132, Italy

  • Inselspital, Bern University Hospital

    Bern, Canton of Bern, 3010, Switzerland

  • Misericordia Hospital

    Grosseto, GR, 58100, Italy

  • Ospedale C. e G. Mazzoni

    Ascoli Piceno, AP, 63100, Italy

  • Ospedale Conegliano

    Conegliano, TV, 31015, Italy

  • Ospedale Santa Maria Goretti, Latina

    Latina, LT, 04100, Italy

  • Ospedale Vito Fazzi

    Lecce, LE, 73100, Italy

  • P.O. San Giuseppe Moscati

    Aversa, CE, 81031, Italy

  • P.O. Umberto I

    Syracuse, SR, 96100, Italy

  • Policlinico University Hospital

    Bari, BA, 70120, Italy

  • Rivoli Hospital

    Rivoli, TO, 10098, Italy

  • San Camillo Hospital

    Roma, RM, 00152, Italy

  • San Giovanni Hospital

    Rome, Rome, 00184, Italy

  • Struttura Complessa di Cardiologia Clinica e Interventistica

    Sassari, SS, 07100, Italy

  • UOSA Cardiologia Interventistica

    Siena, SI, 53100, Italy

  • University Hospital of Patras

    Pátrai, AX, 26504, Greece

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