New heart failure drug shows promise in early trial

NCT ID NCT06215586

Completed Disease control Sponsor: Cardurion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the blood over 12 weeks. The trial is now completed, and results will help determine if further testing is warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tovinontrine

What this could lead to

If successful, this could point toward a new treatment option for chronic heart failure with preserved ejection fraction, potentially improving heart function and symptoms.

What could go wrong

This is a Phase 2 trial with only 303 participants, so results are preliminary. The drug may not show significant benefit over placebo, and side effects are still being evaluated.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder diastolic heart failure heart disorder heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES HEART DISEASES HEART FAILURE HEART FAILURE PRESERVED EJECTION FRACTION

Contacts and locations

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Locations

Cardurion Investigational Site

Dresden, 01067, Germany
Cardurion Investigative Site

Birmingham, Alabama, 35233, United States
Cardurion Investigative Site

Little Rock, Arkansas, 72204, United States
Cardurion Investigative Site

Orange, California, 92868, United States
Cardurion Investigative Site

Torrance, California, 90502, United States
Cardurion Investigative Site

Van Nuys, California, 91405, United States
Cardurion Investigative Site

Jacksonville, Florida, 32216, United States
Cardurion Investigative Site

Miami, Florida, 33137, United States
Cardurion Investigative Site

Hazel Crest, Illinois, 60429, United States
Cardurion Investigative Site

Peoria, Illinois, 61636, United States
Cardurion Investigative Site

Alexandria, Louisiana, 71301, United States
Cardurion Investigative Site

Covington, Louisiana, 70433, United States
Cardurion Investigative Site

St Louis, Missouri, 63110, United States
Cardurion Investigative Site

Buffalo, New York, 14215, United States
Cardurion Investigative Site

New York, New York, 10019, United States
Cardurion Investigative Site

Cleveland, Ohio, 44195, United States
Cardurion Investigative Site

Oklahoma City, Oklahoma, 73135, United States
Cardurion Investigative Site

Portland, Oregon, 97225, United States
Cardurion Investigative Site

Rapid City, South Dakota, 57701, United States
Cardurion Investigative Site

Nashville, Tennessee, 37232-7601, United States
Cardurion Investigative Site

Dallas, Texas, 75246, United States
Cardurion Investigative Site

McKinney, Texas, 75069, United States
Cardurion Investigative Site

Burlington, Vermont, 05401, United States
Cardurion Investigative Site

Chermside, Australia
Cardurion Investigative Site

Bruges, 8000, Belgium
Cardurion Investigative Site

Sint-Niklaas, 9100, Belgium
Cardurion Investigative Site

Burgas, 8008, Bulgaria
Cardurion Investigative Site

Gabrovo, 5300, Bulgaria
Cardurion Investigative Site

Plovdiv, 4002, Bulgaria
Cardurion Investigative Site

Plovdiv, 4003, Bulgaria
Cardurion Investigative Site

Rousse, 7000, Bulgaria
Cardurion Investigative Site

Sofia, 1000, Bulgaria
Cardurion Investigative Site

Stara Zagora, 6000, Bulgaria
Cardurion Investigative Site

Cambridge, Ontario, N1R 6V6, Canada
Cardurion Investigative Site

Hamilton, Ontario, L8L 2X2, Canada
Cardurion Investigative Site

Chicoutimi, Quebec, G7H 7K9, Canada
Cardurion Investigative Site

Montreal, Quebec, Canada
Cardurion Investigative Site

Sherbrooke, Quebec, J1G 2E8, Canada
Cardurion Investigative Site

Trois-Rivières, Quebec, G8Z 3R9, Canada
Cardurion Investigative Site

Hradec Králové, 500 02, Czechia
Cardurion Investigative Site

Hradec Králové, 50005, Czechia
Cardurion Investigative Site

Prague, 128 02, Czechia
Cardurion Investigative Site

Elsterwerda, Brandenburg, 04910, Germany
Cardurion Investigative Site

Papenburg, Lower Saxony, 26871, Germany
Cardurion Investigative Site

Brandenburg, State of Berlin, 10787, Germany
Cardurion Investigative Site

Magdeburg, 39120, Germany
Cardurion Investigative Site

Balatonfüred, 8230, Hungary
Cardurion Investigative Site

Budapest, H-1122, Hungary
Cardurion Investigative Site

Gyöngyös, 3200, Hungary
Cardurion Investigative Site

Hatvan, 3000, Hungary
Cardurion Investigative Site

Orosháza, 5900, Hungary
Cardurion Investigative Site

Milan, 20138, Italy
Cardurion Investigative Site

Eindhoven, 5504 DL, Netherlands
Cardurion Investigative Site

Groningen, 9713 AP, Netherlands
Cardurion Investigative Site

Hardenberg, 7772 SE, Netherlands
Cardurion Investigative Site

Sneek, 8601 ZR, Netherlands
Cardurion Investigative Site

Zutphen, 7207 AE, Netherlands
Cardurion Investigative Site

Dunedin, New Zealand
Cardurion Investigative Site

Grodzisk Mazowiecki, 05-825, Poland
Cardurion Investigative Site

Lodz, 92-213, Poland
Cardurion Investigative Site

Lublin, 20-011, Poland
Cardurion Investigative Site

Sopot, 81-717, Poland
Cardurion Investigative Site

Torun, 87-100, Poland
Cardurion Investigative Site

Warsaw, Poland
Cardurion Investigative Site

Wroclaw, 50-556, Poland
Cardurion Investigative Site

Wroclaw, 50-981, Poland
Cardurion Investigative Site

Córdoba, 14004, Spain
Cardurion Investigative Site

Málaga, 29010, Spain
Cardurion Investigative Site

Santiago de Compostela, 15706, Spain
Cardurion Investigative Site

Seville, 41009, Spain
Cardurion Investigative Site

Valencia, 46026, Spain
Cardurion Investigative Site

Kaohsiung City, Taiwan
Cardurion Investigative Site

Taipei, Taiwan
Cardurion Investigative Site

Taipei County, Taiwan
Cardurion Investigative Site

Taoyuan, Taiwan
Cardurion Investigative Site

Bridgend, CF31 1RQ, United Kingdom
Cardurion Investigative Site

Chichester, PO19 6SE, United Kingdom
Cardurion Investigative Site

Dundee, DD1 9SY, United Kingdom
Cardurion Investigative Site

Glasgow, G81 4DY, United Kingdom
Cardurion Investigative Site

Harrow, HA1 3UJ, United Kingdom
Cardurion Investigative Site

Isleworth, TW7 6AF, United Kingdom
Cardurion Investigative Site

London, SE5 9RS, United Kingdom
Cardurion Investigative Site

London, W1T 7HA, United Kingdom
Cardurion Investigative Site

Southampton, SO16 6YD, United Kingdom