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New shot aims to keep pericarditis Flare-Ups at bay

NCT ID NCT07288216

Recruiting now Disease control Sponsor: Kiniksa Pharmaceuticals International, plc Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This study tests a new drug called KPL-387 in 80 people with well-controlled recurrent pericarditis (inflammation around the heart). The goal is to see if patients can safely switch from their current treatments to KPL-387 alone and still prevent flare-ups. The trial will measure how many people stay free of recurrence and track quality of life over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
KPL-387 (given as a shot under the skin)
What this could lead to
If successful, this could offer a new maintenance treatment option for people with recurrent pericarditis, potentially reducing flare-ups and reliance on standard therapies.
What could go wrong
This is an early Phase 2 study with only 80 participants, so results may not apply to everyone. The drug may not prevent recurrences better than current treatments, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart disorder idiopathic recurrent pericarditis pericarditis Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART DISEASES PERICARDITIS RECURRENT PERICARDITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Investigational Site 001

    RECRUITING

    Norfolk, Virginia, 23507, United States

  • Investigational Site 002

    RECRUITING

    Santa Monica, California, 90404, United States

  • Investigational Site 003

    RECRUITING

    New York, New York, 10032, United States

  • Investigational Site 004

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Investigational Site 005

    RECRUITING

    Austin, Texas, 78705, United States

  • Investigational Site 006

    RECRUITING

    Houston, Texas, 77030, United States

  • Investigational Site 007

    RECRUITING

    London, SE1 7EH, United Kingdom

  • Investigational Site 008

    RECRUITING

    Richmond, Virginia, 23284, United States

  • Investigational Site 009

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • Investigational Site 010

    RECRUITING

    Ottawa, Ontario, K1N 6N5, Canada

  • Investigational Site 011

    RECRUITING

    New York, New York, 10016, United States

  • Investigational Site 012

    RECRUITING

    London, EC1A 7BE, United Kingdom

  • Investigational Site 013

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Investigational Site 014

    RECRUITING

    Los Angeles, California, 90048, United States

  • Investigational Site 015

    RECRUITING

    Barcelona, 08035, Spain

  • Investigational Site 016

    RECRUITING

    Madrid, 28850, Spain

  • Investigational Site 017

    RECRUITING

    Madrid, 28034, Spain

  • Investigational Site 018

    RECRUITING

    Valencia, 46015, Spain

  • Investigational Site 019

    RECRUITING

    Barcelona, 08017, Spain

  • Investigational Site 020

    RECRUITING

    Warsaw, 02-507, Poland

  • Investigational Site 021

    RECRUITING

    Milan, 20157, Italy

  • Investigational Site 022

    RECRUITING

    London, NW3 2QG, United Kingdom

  • Investigational Site 023

    RECRUITING

    Nea Ionia, 142 33, Greece

  • Investigational Site 024

    RECRUITING

    Voula, 166 73, Greece

  • Investigational Site 025

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Investigational Site 026

    RECRUITING

    Poitiers, 86000, France

  • Investigational Site 027

    RECRUITING

    Paris, 75013, France

  • Investigational Site 028

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Investigational Site 029

    RECRUITING

    Belgrade, 11040, Serbia

  • Investigational Site 030

    RECRUITING

    Belgrade, 1100, Serbia

  • Investigational Site 031

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Investigational Site 032

    RECRUITING

    Toulouse, 31400, France

  • Investigational Site 033

    RECRUITING

    Udine, 33100, Italy

  • Investigational Site 034

    RECRUITING

    Genoa, 16147, Italy

  • Investigational Site 035

    RECRUITING

    Athens, 115 28, Greece

  • Investigational Site 036

    RECRUITING

    Padua, 35143, Italy

  • Investigational Site 037

    RECRUITING

    Varese, 21100, Italy

  • Investigational Site 038

    RECRUITING

    Toulouse, 31400, France

  • Investigational Site 039

    RECRUITING

    Jacksonville, Florida, 32224, United States

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