Heart bypass showdown: does using more arteries help women?

NCT ID NCT04124120

Recruiting now Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether using multiple arteries during coronary bypass surgery improves outcomes for women compared to using just one artery. About 2,300 women will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to see if the multiple-graft approach reduces major heart problems and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure (arterial grafting)
What this could lead to: If multiple arterial grafts prove better, this could lead to a new standard of care for women having coronary bypass surgery, reducing heart attacks, strokes, and repeat procedures.
What could go wrong: This is a large trial but still recruiting; results may not show a clear benefit for all women, and surgery carries inherent risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY BYPASS GRAFTING CORONARY ARTERY DISEASE HEART DISEASES

Contacts and locations

Locations

Aalborg University Hospital
RECRUITING

Aalborg, 9000, Denmark
Acibadem-Sistina Hospital
RECRUITING

Skopje, North Macedonia
Allegheny General Hospital
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Anthea Hospital
RECRUITING

Bari, 70124, Italy
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75204, United States
Baystate Health
RECRUITING

Springfield, Massachusetts, 01199, United States
Blackpool Teaching Hospitals NHS Trust
RECRUITING

Blackpool, Lancashire, FY3 8NR, United Kingdom
Careggi University Hospital
RECRUITING

Florence, 50134, Italy
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centro Hospitalar Lisboa Ocidental
NOT_YET_RECRUITING

Lisbon, 1300-598, Portugal
Centro Hospitalar e Universitário Sao Joao
RECRUITING

Porto, 4200-072, Portugal
Cleveland Clinic Foundation
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Corewell Health William Beaumont University Hospital
RECRUITING

Royal Oak, Michigan, 48073, United States
Dedinje Cardiovascular Institute
RECRUITING

Belgrade, 11000, Serbia
Deutsches Herzzentrum der Charite
RECRUITING

Berlin, Germany
Duisburg Heart Center
NOT_YET_RECRUITING

Duisburg, 47137, Germany
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Dusseldorf University
RECRUITING

Düsseldorf, 40225, Germany
East Carolina University
RECRUITING

Greenville, North Carolina, 27858, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Englewood Health
RECRUITING

Englewood, New Jersey, 07631, United States
Erasmus Medical Center
RECRUITING

Rotterdam, South Holland, 3015, Netherlands
Essen University
RECRUITING

Essen, 45147, Germany
European Hospital
RECRUITING

Roma, 00149, Italy
Fondazione Poliambulanza
NOT_YET_RECRUITING

Brescia, 25124, Italy
Frankfurt University
NOT_YET_RECRUITING

Frankfurt, 60323, Germany
Fraser Clinical Trials
RECRUITING

New Westminster, Canada
Fuwai Hospital China
COMPLETED

Beijing, Beijing Municipality, 100037, China
G Kuppuswamy Naidu Memorial Hospital (GKNM)
COMPLETED

Coimbatore, Tamil Nadu, 641037, India
General University Hospital, Prague
NOT_YET_RECRUITING

New Town, 128 08, Czechia
Genesis Healthcare System
RECRUITING

Zanesville, Ohio, 43701, United States
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom
Guy's and St Thomas' NHS Foundation Trust - St Thomas' Hospital
RECRUITING

London, United Kingdom
HDZ NRW Bad Oeynhausen Germany
RECRUITING

Bad Oeynhausen, 32545, Germany
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Health Sciences North
RECRUITING

Greater Sudbury, Ontario, P3E 5J1, Canada
Heart Center Herzzentrum, Leipzig
RECRUITING

Leipzig, 04289, Germany
Heart Institute University of São Paulo
RECRUITING

São Paulo, 05508, Brazil
Heidelberg University
RECRUITING

Heidelberg, Germany
Hopital Sacre-Coeur
RECRUITING

Montreal, Canada
Horizon Health Network - Saint John Regional Hospital
RECRUITING

Saint John, New Brunswick, E2L 4L2, Canada
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico de San Carlos
RECRUITING

Madrid, Spain
Hospital Universitario del Vinalopo
RECRUITING

Elche, Alicante, 03293, Spain
Hull University Hospitals
RECRUITING

Hull, United Kingdom
Humanitas Gavazzeni of Bergamo
RECRUITING

Bergamo, 24125, Italy
Imperial College Healthcare NHS Trust
RECRUITING

London, W2 1NY, United Kingdom
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Innsbruck Medical University
RECRUITING

Innsbruck, 6020, Austria
Institut Universitaire de Cardiologie et de Pneumologie de Québec
RECRUITING

Ste Foy, Quebec, G1V 4G5, Canada
Institute of Cardiology Porto Alegre
NOT_YET_RECRUITING

Porto Alegre, 9062000, Brazil
Instituto Dante Pazzanese de Cardiologia
NOT_YET_RECRUITING

Vila Mariana, 04012-909, Brazil
Jena University Hospital
RECRUITING

Jena, 07743, Germany
Jilin Heart Hospital China
COMPLETED

Changchun, Jilin, 130052, China
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21218, United States
Karonlinska University Hospital
RECRUITING

Stockholm, 171 76, Sweden
Kepler University Hospital
RECRUITING

Linz, Austria
Krankenhaus Nord Vienna North Hospital
RECRUITING

Vienna, 1210, Austria
Krankenhaus der Barmherzigen Brüder Trier
RECRUITING

Trier, 54292, Germany
Lankenau Medical Center
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Leiden University Medical Center
RECRUITING

Leiden, South Holland, 2333, Netherlands
Lenox Hill Hospital
NOT_YET_RECRUITING

New York, New York, 10075, United States
Liverpool Heart and Chest Hospital Foundation Trust
RECRUITING

Liverpool, L14 3PE, United Kingdom
London Health Sciences
RECRUITING

London, Ontario, N6A 5A5, Canada
Maastricht University Medical Centre
RECRUITING

Maastricht, 6229, Netherlands
Manchester University NHS Trust
RECRUITING

Manchester, M13 9WL, United Kingdom
Maria Cecilia Hospital GVM
NOT_YET_RECRUITING

Cotignola, 48033, Italy
Mazankowski Alberta Heart Institute
RECRUITING

Edmonton, Alberta, Canada
Medical University Gdansk
RECRUITING

Gdansk, 80-210, Poland
Medical University of Graz
RECRUITING

Graz, 8010, Austria
Medical University of Silesia
RECRUITING

Katowice, 40-055, Poland
Medical University of Vienna
RECRUITING

Vienna, 1090, Austria
Methodist Physicians Health
RECRUITING

Omaha, Nebraska, 68118, United States
Mid and South Essex NHS Foundation Trust
RECRUITING

Westcliff-on-Sea, United Kingdom
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
NHS Golden Jubilee
RECRUITING

Clydebank, G81 4DY, United Kingdom
National Research Medical Center of the Russian Academy of Sciences - Tomsk, Russia
COMPLETED

Tomsk, Russia
National Taiwan University Hospital
NOT_YET_RECRUITING

Zhongzheng, Taipei, 100229, Taiwan
National University of Singapore
NOT_YET_RECRUITING

Singapore, 119077, Singapore
NavarraBiomed
RECRUITING

Pamplona, Spain
Nebraska Heart Hospital
NOT_YET_RECRUITING

Lincoln, Nebraska, 68526, United States
New York Presbyterian Queens
RECRUITING

Queens, New York, 11355, United States
NewYork-Presbyterian Brooklyn Methodist Hospital
RECRUITING

Brooklyn, New York, 11215, United States
Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
Newfoundland and Labrador Health Services
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3R4, Canada
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Ospedale Le Molinette, Torino
NOT_YET_RECRUITING

Torino, 10126, Italy
Oxford University Hospitals NHS Trust
RECRUITING

Multiple Locations, Oxford, United Kingdom
Pomona Valley Hospital Medical Center
RECRUITING

Pomona, California, 91767, United States
Rambam Health Care Campus
COMPLETED

Haifa, 3109601, Israel
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Robert-Bosch-Hospital Stuttgart Germany
NOT_YET_RECRUITING

Stuttgart, 70376, Germany
Royal Papworth NHS Foundation Trust
RECRUITING

Cambridge, CB2 0A, United Kingdom
Royal Victoria Hospital
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Royal Wolverhampton NHS Trust
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
COMPLETED

Shanghai, Shanghai Municipality, 200025, China
Sahlgrenska University Hospital
RECRUITING

Gothenburg, Sweden
Saitama Medical University Japan
NOT_YET_RECRUITING

Saitama, 350-0451, Japan
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Severance Cardiovascular Hospital, Yonsei University College of Medicine
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, S10 2SB, United Kingdom
South Tees Hospitals NHS Trust
RECRUITING

Middlesbrough, TS4 3BW, United Kingdom
St George's University Hospitals
RECRUITING

London, United Kingdom
St. Boniface General Hospital
RECRUITING

Winnipeg, Manitoba, R2H 2A6, Canada
Star Hospitals - Hyderabad, India
COMPLETED

Hyderabad, Telangana, 500034, India
Sunnybrook Health Sciences
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
TUM University Hospital German Heart Center
RECRUITING

Munich, Germany
Teda Hospital Tianjin China
COMPLETED

Tianjin, Tianjin Municipality, 300456, China
The Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
The University of Melbourne
RECRUITING

Melbourne, Australia
The University of Texas Medical Health Branch at Galveston
RECRUITING

Galveston, Texas, 77550, United States
The Valley Hospital
RECRUITING

Ridgewood, New Jersey, 07450, United States
Tokyo Medical and Dental University
NOT_YET_RECRUITING

Bunkyō-Ku, Tokyo, 113-8510, Japan
Toronto General Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2C4, Canada
UT Health San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Universita' Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
University Hospital Coimbra
RECRUITING

Coimbra, 3004-561, Portugal
University Hospital Dubrava
RECRUITING

Zagreb, 10000, Croatia
University Hospital Erlangen
COMPLETED

Erlangen, 91054, Germany
University Hospital of Giessen and Marburg
RECRUITING

Giessen, 35385, Germany
University Hospital of Montreal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
University Hospitals of Leicester
RECRUITING

Leicester, United Kingdom
University Hospitals of North Midlands NHS Trust
RECRUITING

Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
University Hradec Králové
RECRUITING

Hradec Králové, 500 03, Czechia
University Medical Center of Göttingen
RECRUITING

Göttingen, 37075, Germany
University of California, San Francisco
RECRUITING

San Francisco, California, 94118, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Massachusetts Chan Medical School
COMPLETED

Worcester, Massachusetts, 01655, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48104, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
Universitäts-Herzzentrum Bad Krozingen Freiburg
RECRUITING

Bad Krozingen, Baden-Wurttemberg, 79189, Germany
Victorian Heart Hospital
RECRUITING

Clayton, 3168, Australia
Wake Forest University
RECRUITING

Winston-Salem, North Carolina, 27106, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Yale University Hospital
RECRUITING

New Haven, Connecticut, 06510, United States
Zbigniew Religa Lower Silesian Heart Disease Centre
RECRUITING

Zabrze, 41-800, Poland

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