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Homemade PRP could be a cheap fix for knee pain

NCT ID NCT06184048

Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a low-cost way to make platelet-rich plasma (PRP) from a patient's own blood for knee osteoarthritis. Twenty adults with mild to moderate knee OA received two injections of this homemade PRP. The main goal was to see if the PRP had enough platelets, similar to expensive commercial kits. Researchers also tracked pain and function for a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) made from the patient's own blood
What this could lead to
If this low-cost PRP works as well as commercial kits, it could offer a cheaper, safer option for knee osteoarthritis pain relief.
What could go wrong
This was a small, early validation study with only 20 participants. It focused on whether the PRP composition matched commercial kits, not on proving it reduces pain better than standard treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients of any adult age with symptomatic Kellgren-Lawrence (K-L) score 1-3 knee OA, based on radiographs within the last six months. 2. Patients must have failed at least six weeks of conventional conservative treatments (such as medication or physical therapy). 3. Patients with bilateral knee OA will only be eligible if both knees fit the criteria; each knee will count separately. Exclusion Criteria: 1. Recent (last two years) knee surgery, 2. Prior orthobiologic injection(s) into the knee, 3. Known major axial deviation (over 30 degrees) 4. Known thrombocytopenia (platelets under 50,000), thrombocythemia (platelets over 1,000,000), known platelet disorder (ITP, TTP, or Lowe syndrome) 5. Active systemic infection requiring antibiotics, or local infection at the site of injection, 6. Non-ambulatory patients, 7. Patients seeking care with active litigation pending 8. Body mass index (BMI) over 40 9. Injection into the affected joint within the last six months 10. Oral steroids consumed within the last three months.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (OA) Platelet rich plasma (PRP)

Contacts and locations

Locations

  • University of Utah Orthopedic Center

    Salt Lake City, Utah, 84108, United States

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