Could amniotic fluid beat steroids for spinal stenosis pain?

NCT ID NCT04537026

Completed Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether an injection of amniotic fluid, a natural anti-inflammatory, works better than a standard steroid injection for chronic back and leg pain caused by spinal stenosis. Sixty-one adults who had not improved with other treatments were randomly assigned to receive either the amniotic fluid or a steroid. The goal was to see if the amniotic fluid could reduce pain and disability with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: amniotic fluid allograft
What this could lead to: If it works, this could offer a safer, longer-lasting option for chronic back and leg pain from spinal stenosis, helping people avoid surgery.
What could go wrong: This is an early-phase trial with only 61 people, so results may not apply widely. The amniotic fluid treatment might not be more effective than the standard steroid injection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lumbar spinal stenosis spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUMBAR SPINAL STENOSIS

Contacts and locations

Locations

University of Utah Orthopaedic Center

Salt Lake City, Utah, 84108, United States

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