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New procedure may ease knee pain after replacement surgery

NCT ID NCT05130216

Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether radiofrequency ablation (RFA) of the genicular nerves can reduce chronic knee pain in people who had a total knee replacement at least a year ago. Five participants with moderate to severe pain received the procedure. The goal was to see if RFA provides meaningful pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation
What this could lead to
If it works, this could offer a non-surgical option for people with lingering knee pain after joint replacement.
What could go wrong
This was a very small pilot study with only 5 people, so results may not apply to everyone. The procedure also carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

5 people

The number who actually took part.

Started

Sep 2021

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who have high pain following total knee replacement identified in clinic.

Ages

30 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 30 to 90 years * At least one year post TKA * Have no indications for revision TKA * ≥4/10 knee pain for \>6 months following TKA * ≥80% relief with diagnostic genicular nerve blocks * Willingness to undergo fluoroscopy-guided genicular nerve RFA treatment. Exclusion Criteria: * Conditions that preclude RFA (e.g. pregnancy, pacemaker/ICD, severe cardiac/pulmonary compromise; acute illness/infection; coagulopathy or bleeding disorder; allergic reactions/contraindications to a local anesthetic. * Inability to write, speak or read in English * Patient refusal * Significant psychiatric comorbidity

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee arthroplasty

Contacts and locations

Locations

  • University of Utah Orthopaedic Center

    Salt Lake City, Utah, 84108, United States

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