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Prepping the knee before surgery: a new approach to better recovery

NCT ID NCT07790146

Disease control Sponsor: Samara State Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether a 4-week prehabilitation program before total knee replacement can improve recovery. The program includes physical therapy, breathing exercises, psychological support, and targeted treatments based on each person's osteoarthritis type. Researchers will compare outcomes like pain, function, and mobility in 64 adults with severe knee osteoarthritis. The goal is to see if preparing the knee and body before surgery leads to better results and quality of life afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A 4-week preoperative program combining physical therapy, breathing exercises, psychological support, and targeted treatments based on osteoarthritis type, before knee replacement surgery.
What this could lead to
If effective, this approach could reduce pain and improve mobility and satisfaction after knee replacement, helping more people recover fully.
What could go wrong
The trial is small and early, so results may not apply to everyone. The program adds time before surgery, and some people may not benefit or may find it burdensome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Jan 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 70 years * Verified knee OA stage III-IV (Kellgren-Lawrence) * Intermalleolar distance ≤ 8 cm (valgus) or intercondylar distance ≤ 8 cm (varus) * Limb shortening ≤ 2 cm * BMI \< 35 kg/m² * Barthel Index \> 65 points * No decompensation of concomitant chronic diseases * No recent physiotherapy or intra-articular injections (within 1-3 months) * Signed informed consent Exclusion Criteria: * Age \< 18 or \> 70 years * Limb shortening \> 2 cm * Previous knee surgery or trauma indicating secondary OA * BMI ≥ 35 kg/m² * Decompensated chronic infectious or non-infectious diseases * Inability to comply with the follow-up schedule

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis Total knee arthroplasty

Contacts and locations

Locations

  • Clinics of Samara State Medical University, Department of Traumatology and Orthopedics

    Samara, Samara Oblast, 443099, Russia

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