Oxygen test during pregnancy may predict brain development in Heart-Defect babies
NCT ID NCT05767385
First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time
Summary
This study looks at how blood flow to the fetal brain is affected in babies with congenital heart disease and whether it relates to their development after birth. Pregnant women with a fetus known or suspected to have a heart defect will have a fetal echocardiogram, then breathe extra oxygen for 10 minutes to see how the brain's blood vessels respond. After birth, babies will take a neurobehavioral test to link brain blood flow patterns with developmental outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- maternal hyperoxia (8 liters of 100% oxygen via face mask for 10 minutes)
- What this could lead to
- If successful, this could help identify babies at risk for developmental delays before birth, allowing early intervention.
- What could go wrong
- This is an observational study with a small intervention, so it cannot prove cause and effect. Results may not apply to all types of congenital heart disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COMPLEX CONGENITAL HEART DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
-
Maine Medical Center
Scarborough, Maine, 04074, United States
-
Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
-
University of California San Francisco
San Francisco, California, 94143, United States
-
University of Utah
Salt Lake City, Utah, 84132, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Thin air, thicker blood? hypoxia training may supercharge red blood cell production — at a cost
- Could a smartphone app help babies see better?
- Could a prebiotic diet boost brain development in preterm babies?
- Hidden toll of routine ICU procedure revealed: suctioning may spike pain and stress
- Scientists track rare genetic disorder to map its hidden trajectory
- Massive global registry aims to unlock secrets of rett syndrome