Guarana: a natural energy boost for cancer fatigue?

NCT ID NCT07151391

Recruiting now Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether guarana, a natural supplement from the Amazon, can reduce fatigue in 86 people with neuroendocrine tumors or gynecologic cancers. Participants take either guarana or a placebo daily for up to 42 days, and researchers measure changes in fatigue using standard questionnaires. The goal is to see if guarana offers a safe, simple way to improve energy and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: guarana (Paullinia cupana) taken as a 500 mg oral capsule daily
What this could lead to: If it works, this could offer a natural, low-cost option to reduce fatigue in people with these cancers, improving daily life.
What could go wrong: This is a small, early-phase trial (86 people) testing a supplement, not a proven drug. Fatigue is subjective, and results may not be strong or lasting. Side effects are possible.

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Conditions

The condition(s) this trial relates to.

endometrial cancer fallopian tube cancer female reproductive organ cancer neuroendocrine neoplasm ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GYNECOLOGIC CANCER NEUROENDOCRINE TUMORS

Contacts and locations

Locations

Huntsman Cancer Institute at University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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