Could a shorter radiation course be just as good for endometrial cancer?

NCT ID NCT03422198

Recruiting now Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a shorter course of vaginal cuff brachytherapy (internal radiation) to the standard longer course for people with stage I-II endometrial cancer. The main goal is to see if the shorter treatment improves quality of life and reduces financial burden, while still controlling the cancer. About 188 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vaginal cuff brachytherapy (internal radiation)
What this could lead to: If successful, this could offer a shorter, more convenient radiation treatment for early endometrial cancer, reducing side effects and improving quality of life.
What could go wrong: This is a Phase 3 trial, but it's relatively small (188 participants). The shorter course may not control cancer as well as the standard, and results may not apply to all types of endometrial cancer.

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Conditions

The condition(s) this trial relates to.

carcinosarcoma of the corpus uteri endometrial clear cell adenocarcinoma endometrial endometrioid adenocarcinoma endometrial serous adenocarcinoma uterine corpus cancer uterine corpus sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CLEAR CELL ADENOCARCINOMA ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA ENDOMETRIAL SEROUS ADENOCARCINOMA STAGE I UTERINE CORPUS CANCER STAGE IA UTERINE CORPUS CANCER STAGE IB UTERINE CORPUS CANCER STAGE II UTERINE CORPUS CANCER UTERINE CORPUS CARCINOSARCOMA UTERINE CORPUS SARCOMA

Contacts and locations

Locations

Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Intermountain Medical Center / LDS Hospital
COMPLETED

Salt Lake City, Utah, 84143, United States
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
MD Anderson
RECRUITING

Houston, Texas, 77030, United States
Stanford Cancer Center
COMPLETED

Palo Alto, California, 94304, United States

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