Experimental drug triapine tested in rare uterine cancer before surgery

NCT ID NCT04494113

Ongoing Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing the drug triapine in 12 women with a rare and aggressive type of uterine cancer called uterine serous adenocarcinoma. Participants receive a single dose of triapine before their scheduled hysterectomy, and researchers analyze tissue samples to see how the drug affects cancer cells. The goal is to understand if triapine can slow tumor growth, not yet to prove it works as a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Triapine (a drug given intravenously that may block enzymes needed for cancer cell growth)
What this could lead to: If successful, this could point toward a new treatment option for uterine serous adenocarcinoma, a rare and aggressive cancer.
What could go wrong: This is a very early (phase 0) trial with only 12 participants, so results are preliminary and may not lead to a proven treatment. The drug may also cause side effects like low blood cell counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial serous adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL SEROUS ADENOCARCINOMA

Contacts and locations

Locations

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

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