Can a stronger zap to brain tumors be safer? new trial aims to find out

NCT ID NCT02390518

Recruiting now Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This early-stage trial tests whether giving a higher dose of focused radiation (stereotactic radiosurgery) to brain metastases is safe. About 50 people with 1 to 5 brain tumors who have never had brain radiation will receive an experimental dose on one tumor, while other tumors get standard doses. The goal is to find the highest dose that does not cause severe side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stereotactic radiosurgery (high-dose radiation)
What this could lead to: If successful, this could establish a safer, more effective radiation dose for treating brain metastases that have not been previously irradiated.
What could go wrong: This is an early Phase I trial with only 50 participants, so results may not apply broadly. Higher radiation doses also carry increased risk of brain toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States

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