New drug duo aims to shrink Hard-to-Treat tumors

NCT ID NCT05405595

Recruiting now Disease control Sponsor: Adagene Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called ADG126 combined with pembrolizumab (a standard immunotherapy) in people with advanced or metastatic solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 186 adults will take part in this early-phase trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colorectal cancer metastatic malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED/METASTATIC SOLID TUMORS

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
CHA Bundang Medical Center, CHA university
RECRUITING

Seongnam, Gyeonggido, 13496, South Korea
Chungbuk National University Hospital
RECRUITING

Cheongju-si, North Chungcheong, 28644, South Korea
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope Orange County
RECRUITING

Irvine, California, 92618, United States
Dong -A University Hospital
TERMINATED

Seogu, Busan Gwangyeogsi, 49201, South Korea
Florida cancer specialist/Sarah Cannon Research Institute
ACTIVE_NOT_RECRUITING

Sarasota, Florida, 34232, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, China
Hong Kong Humanity & Health Clinical Trial Center
RECRUITING

Hong Kong, Hong Kong, China
Honor Health Research Institute
RECRUITING

Scottsdale, Arizona, 85251, United States
KangBuk Samsung Hospital
TERMINATED

Seoul, 03081, South Korea
Keimyung University Dongsan Hospital
TERMINATED

Daegu, 41931, South Korea
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Prince of Wales Hospital
RECRUITING

Hong Kong, Hong Kong, China
Samsung Medical Center
RECRUITING

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
SunYat-Sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, China
The Catholic University of Korea Street. Vincent Hospital
TERMINATED

Suwon, Gyeonggido, 16247, South Korea
The Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195-0001, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.