Experimental 'Drug Vesicles' injected into spine aim to fight lung cancer brain spread
NCT ID NCT07559097
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether injecting methotrexate-loaded vesicles (tiny drug-carrying particles made from patients' own tumor cells) into the spinal fluid can safely treat lung cancer that has spread to the brain lining. About 14 adults who have failed standard treatments will receive the injections on a schedule. The study first finds the safest dose, then checks if it shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methotrexate-loaded vesicles (drug-carrying particles made from patients' own tumor cells)
What this could lead to
If it works, this could offer a new local treatment option for lung cancer that has spread to the brain lining, potentially controlling the disease and extending survival.
What could go wrong
This is a very early, small trial (14 people) testing safety and dosing first. The approach may not work or could cause serious side effects like nerve damage or infection from the spinal injections.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Wang Qiming
RECRUITINGZhengzhou, Henan, 450000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••