Can a Two-Drug attack reach cancer hiding in the brain?

This trial is testing whether combining two drugs—amivantamab given intravenously and pemetrexed injected directly into the spinal fluid—can safely help people with a specific type of lung cancer that has spread to the membranes around the brain and spinal cord. This condition, called leptomeningeal metastasis, is hard to treat because many cancer drugs don't reach high enough levels in the spinal fluid. The study will include adults with EGFR-mutated lung adenocarcinoma and will monitor side effects, how long participants live without the disease worsening, and overall survival.