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New hope for tumors that beat immunotherapy? early trial launches

NCT ID NCT06270706

Recruiting now Disease control Sponsor: Pliant Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This early-phase study tests a new drug (PLN-101095) alone or with pembrolizumab in adults whose advanced solid tumors have stopped responding to standard immunotherapy. About 124 participants will receive the treatment to check safety and early signs of tumor shrinkage. The goal is to find a safe dose and see if the combination can re-sensitize tumors to immunotherapy.

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Conditions

The condition(s) this trial relates to.

anus neoplasm cholangiocarcinoma colorectal neoplasm endometrium neoplasm melanoma metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma ovarian cancer renal cell carcinoma transitional cell carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC SOLID TUMOR

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Carolina Cancer Research Center

    RECRUITING

    Wilson, North Carolina, 27893, United States

    Contact Email: •••••@•••••

  • NEXT Austin

    RECRUITING

    Austin, Texas, 78758, United States

    Contact Email: •••••@•••••

  • NEXT Houston

    RECRUITING

    Houston, Texas, 77054, United States

    Contact Email: •••••@•••••

  • NEXT Virginia

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Email: •••••@•••••

  • START Center for Clinical Research

    RECRUITING

    Fort Worth, Texas, 76104, United States

    Contact Email: •••••@•••••

  • START Mountain Region

    RECRUITING

    West Valley City, Utah, 84119, United States

    Contact Email: •••••@•••••

  • START New Jersey

    RECRUITING

    East Brunswick, New Jersey, 08816, United States

    Contact Email: •••••@•••••

  • START New York Long Island LLC

    RECRUITING

    Lake Success, New York, 11042, United States

    Contact Email: •••••@•••••

  • South Texas Accelerated Research Therapeutics (START)

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

    Contact Email: •••••@•••••

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • Winship Cancer Institute of Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Email: •••••@•••••

  • Yale University

    ACTIVE_NOT_RECRUITING

    New Haven, Connecticut, 06511, United States

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